MTA1

MTA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BKX, 4PBY, 4PBZ, 4PC0, 5ICN, 5FXY
Identifiers
Aliases	MTA1, metastasis associated 1
External IDs	MGI: 2150037 HomoloGene: 3442 GeneCards: MTA1
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • core promoter binding • transcription corepressor activity • transcription factor activity, sequence-specific DNA binding • transcription coactivator activity • zinc ion binding • chromatin binding • metal ion binding • core promoter sequence-specific DNA binding • protein binding • RNA polymerase II repressing transcription factor binding • histone deacetylase activity Cellular component • cytoplasm • nuclear envelope • intracellular membrane-bounded organelle • nucleoplasm • microtubule • cytoskeleton • nucleus • cytosol Biological process • response to ionizing radiation • regulation of transcription, DNA-templated • regulation of gene expression, epigenetic • rhythmic process • protein sumoylation • circadian regulation of gene expression • transcription, DNA-templated • positive regulation of protein autoubiquitination • double-strand break repair • entrainment of circadian clock by photoperiod • signal transduction • proteasome-mediated ubiquitin-dependent protein catabolic process • locomotor rhythm • histone deacetylation • negative regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9112	116870
Ensembl	ENSG00000182979	ENSMUSG00000021144
UniProt	Q13330	Q8K4B0
RefSeq (mRNA)	NM_001203258 NM_004689	NM_054081 NM_001346696
RefSeq (protein)	NP_001190187 NP_004680	NP_001333625 NP_473422
Location (UCSC)	Chr 14: 105.42 – 105.47 Mb	Chr 12: 113.1 – 113.14 Mb
PubMed search

4BKX, 4PBY, 4PBZ, 4PC0, 5ICN, 5FXY

9112

116870

ENSG00000182979

ENSMUSG00000021144

Q13330

Q8K4B0

NM_001203258
NM_004689

NM_054081
NM_001346696

NP_001190187
NP_004680

NP_001333625
NP_473422

Metastasis-associated protein MTA1 is a protein that in humans is encoded by the MTA1 gene. MTA1 is the founding member of the MTA family of genes. MTA1 is primarily localized in the nucleus but also found to be distributed in the extra-nuclear compartments. MTA1 is a component of several chromatin remodeling complexes including the nucleosome remodeling and deacetylation complex (NuRD). MTA1 regulates gene expression by functioning as a coregulator to integrate DNA-interacting factors to gene activity. MTA1 participates in physiological functions in the normal and cancer cells. MTA1 is one of the most upregulated proteins in human cancer and associates with cancer progression, aggressive phenotypes, and poor prognosis of cancer patients.

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