MTA2

MTA2
Identifiers
Aliases	MTA2, MTA1L1, PID, metastasis associated 1 family member 2
External IDs	MGI: 1346340 HomoloGene: 3480 GeneCards: MTA2
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • transcription factor activity, transcription factor binding • RNA polymerase II transcription factor binding • transcription factor activity, sequence-specific DNA binding • zinc ion binding • histone deacetylase binding • chromatin binding • metal ion binding • protein binding • RNA polymerase II repressing transcription factor binding • nucleosomal DNA binding • transcription regulatory region DNA binding • histone deacetylase activity • transcription regulatory region sequence-specific DNA binding Cellular component • histone deacetylase complex • NuRD complex • membrane • transcription factor complex • nucleoplasm • protein complex • nuclear chromatin • nucleus Biological process • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • chromatin assembly or disassembly • ATP-dependent chromatin remodeling • DNA methylation • regulation of fibroblast migration • negative regulation of transcription, DNA-templated • histone deacetylation • positive regulation of transcription from RNA polymerase II promoter • regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9219	23942
Ensembl	ENSG00000149480	ENSMUSG00000071646
UniProt	O94776	Q9R190
RefSeq (mRNA)	NM_004739 NM_001330292	NM_011842
RefSeq (protein)	NP_001317221 NP_004730	NP_035972.3 NP_035972
Location (UCSC)	Chr 11: 62.59 – 62.6 Mb	Chr 19: 8.94 – 8.95 Mb
PubMed search

9219

23942

ENSG00000149480

ENSMUSG00000071646

O94776

Q9R190

NM_004739
NM_001330292

NM_011842

NP_001317221
NP_004730

NP_035972.3
NP_035972

Metastasis-associated protein MTA2 is a protein that in humans is encoded by the MTA2 gene.

MTA2 is the second member of the MTA family of genes. MTA2 protein localizes in the nucleus and is a component of the nucleosome remodeling and the deacetylation complex (NuRD). Similar to the founding family member MTA1, MTA2 functions as a chromatin remodeling factor and regulates gene expression. MTA2 is overexpressed in human cancer and its dysregulated level correlates well with cancer invasiveness and aggressive phenotypes.

MTA2 was initially recognized as an MTA1 like 1 gene, named MTA1-L1, from a large scale sequencing of randomly selected clones from human cDNA libraries in 1999. Clues about the role of MTA2 in gene expression came from the association of MTA2 polypeptides in the NuRD complex in a proteomic study This was followed by targeted cloning of murine Mta2 in 2001.

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