MGluR2

GRM2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4XAQ, 4XAS, 5CNI, 5CNJ
Identifiers
Aliases	GRM2, GPRC1B, MGLUR2, mGlu2, glutamate metabotropic receptor 2, mGluR2
External IDs	MGI: 1351339 HomoloGene: 20229 GeneCards: GRM2
Targeted by Drug
DCG-IV, eglumetad, LY379268, Ro4491533, 4-MPPTS, biphenylindanone A, CBiPES
Gene ontology Molecular function • glutamate receptor activity • G-protein coupled receptor activity • group II metabotropic glutamate receptor activity • calcium channel regulator activity • signal transducer activity • protein binding Cellular component • integral component of membrane • cell projection • membrane • plasma membrane • synapse • integral component of plasma membrane • intracellular • axon • cell junction • dendrite • neuron projection • presynaptic membrane Biological process • G-protein coupled receptor signaling pathway • negative regulation of adenylate cyclase activity • glutamate secretion • signal transduction • chemical synaptic transmission • regulation of synaptic transmission, glutamatergic • adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway • G-protein coupled glutamate receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2912	108068
Ensembl	ENSG00000164082	ENSMUSG00000023192
UniProt	Q14416	Q14BI2
RefSeq (mRNA)	NM_000839 NM_001130063	NM_001160353
RefSeq (protein)	NP_000830 NP_001123535	NP_001153825.1 NP_001153825
Location (UCSC)	Chr 3: 51.71 – 51.72 Mb	Chr 9: 106.64 – 106.66 Mb
PubMed search

4XAQ, 4XAS, 5CNI, 5CNJ

2912

108068

ENSG00000164082

ENSMUSG00000023192

Q14416

Q14BI2

NM_000839
NM_001130063

NM_001160353

NP_000830
NP_001123535

NP_001153825.1
NP_001153825

Metabotropic glutamate receptor 2 is a protein that in humans is encoded by the GRM2 gene.

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 (this receptor) and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

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Wikipedia