Larry E. Overman

Larry E. Overman is Distinguished Professor of Chemistry at the University of California, Irvine. He was born in Chicago in 1943. Overman obtained a B.A. degree from Earlham College in 1965. and he completed his Ph.D. in chemistry from the University of Wisconsin–Madison in 1969, under Howard Whitlock, Jr.. Professor Overman is a member of the United States National Academy of Sciences and the American Academy of Arts and Sciences. He was the recipient of the Arthur C. Cope Award in 2003, and he was awarded the Tetrahedron Prize for Creativity in Organic Chemistry for 2008.

Overman's research is focused on the development of new chemical reactions, particularly transition metal catalyzed reactions, and the application of those reactions toward the synthesis of natural products. Overman is most known for the Overman rearrangement, a Claisen rearrangement of allylic alcohols to give allylic trichloroacetamides.

Overman's Ph.D. focused on the mechanism of rearrangements related to the biosynthesis of lanosterol from squalene oxide via lanosterol synthase. Overman has explained that this work gave him a lifelong love of rearrangement reactions. This was followed by two years as a postdoctoral fellow at Columbia University with Ronald Breslow, using non-covalent binding of cyclodextrin as a model of enzyme binding.