Lanosterol synthase

lanosterol synthase
Identifiers
EC number	5.4.99.7
CAS number	9032-71-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
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PMC	articles
PubMed	articles
NCBI	proteins

LSS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W6J, 1W6K
Identifiers
Aliases	LSS, OSC, CTRCT44, lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase), lanosterol synthase
External IDs	OMIM: 600909 MGI: 1336155 HomoloGene: 37408 GeneCards: LSS
Gene location (Human) Chr. Chromosome 21 (human) Band 21q22.3 Start 46,188,141 bp End 46,228,824 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10 C1|10 39.1 cM Start 76,531,588 bp End 76,557,138 bp
Gene ontology Molecular function • isomerase activity • intramolecular transferase activity • lanosterol synthase activity Cellular component • lipid droplet • endoplasmic reticulum membrane • endoplasmic reticulum • membrane Biological process • regulation of protein stability • lipid metabolic process • steroid biosynthetic process • cholesterol biosynthetic process • regulation of cholesterol biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4047	16987
Ensembl	ENSG00000160285 ENSG00000281289	ENSMUSG00000033105
UniProt	P48449	Q8BLN5
RefSeq (mRNA)	NM_001001438 NM_001145436 NM_001145437 NM_002340	NM_146006
RefSeq (protein)	NP_001001438 NP_001138908 NP_001138909 NP_002331	NP_666118
Location (UCSC)	Chr 21: 46.19 – 46.23 Mb	Chr 21: 76.53 – 76.56 Mb
PubMed search

1W6J, 1W6K

4047

16987

ENSG00000160285
ENSG00000281289

ENSMUSG00000033105

P48449

Q8BLN5

NM_001001438
NM_001145436
NM_001145437
NM_002340

NM_146006

NP_001001438
NP_001138908
NP_001138909
NP_002331

NP_666118

Lanosterol synthase is an oxidosqualene cyclase (OSC) enzyme that converts (S)-2,3-oxidosqualene to a protosterol cation and finally to lanosterol.Lanosterol is a key four-ringed intermediate in cholesterol biosynthesis. In humans, lanosterol synthase is encoded by the LSS gene.

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