LRP2

LRP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M0P
Identifiers
Aliases	LRP2, DBS, GP330, LDL receptor related protein 2
External IDs	MGI: 95794 HomoloGene: 20952 GeneCards: LRP2
Genetically Related Diseases
anorexia nervosa
Gene ontology Molecular function • calcium ion binding • SH3 domain binding • metal ion binding • protein binding • low-density lipoprotein receptor activity • lipoprotein transporter activity Cellular component • integral component of membrane • endosome • Golgi apparatus • membrane • receptor complex • plasma membrane • endocytic vesicle • apical part of cell • brush border membrane • lysosomal membrane • apical plasma membrane • endoplasmic reticulum • brush border • clathrin-coated pit • lysosome • extracellular exosome • clathrin-coated vesicle membrane Biological process • endocytosis • ventricular septum development • vitamin D metabolic process • lipid metabolic process • receptor-mediated endocytosis • coronary vasculature development • retinoid metabolic process • aorta development • heart development • forebrain development • cell proliferation • vitamin metabolic process • lipoprotein transport • membrane organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4036	14725
Ensembl	ENSG00000081479	ENSMUSG00000027070
UniProt	P98164	A2ARV4
RefSeq (mRNA)	NM_004525	NM_001081088
RefSeq (protein)	NP_004516	NP_001074557.1 NP_001074557
Location (UCSC)	Chr 2: 169.13 – 169.36 Mb	Chr 2: 69.42 – 69.59 Mb
PubMed search

2M0P

4036

14725

ENSG00000081479

ENSMUSG00000027070

P98164

A2ARV4

NM_004525

NM_001081088

NP_004516

NP_001074557.1
NP_001074557

Low density lipoprotein-related protein 2 also known as LRP2 or megalin is a protein which in humans is encoded by the LRP2 gene.

LRP2 is a multiligand binding receptor found in the plasma membrane of many absorptive epithelial cells. LRP2 is a member of a family of receptors with structural similarities to the low density lipoprotein receptor (LDLR). LRP2 functions to mediate endocytosis of ligands leading to degradation in lysosomes or transcytosis. LRP2 (previously called glycoprotein 330) together with RAP (LRPAP1) forms the Heymann nephritis antigenic complex. LRP2 can also form complexes with cubilin: those complexes are able to reabsorb several molecules and can be inhibited by sodium maleate. LRP2 is expressed in epithelial cells of the thyroid (thyrocytes), where it can serve as a receptor for the protein thyroglobulin (Tg).

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Wikipedia