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LRP2

LRP2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LRP2, DBS, GP330, LDL receptor related protein 2
External IDs MGI: 95794 HomoloGene: 20952 GeneCards: LRP2
Genetically Related Diseases
anorexia nervosa
RNA expression pattern
PBB GE LRP2 205710 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004525

NM_001081088

RefSeq (protein)

NP_004516

NP_001074557.1
NP_001074557

Location (UCSC) Chr 2: 169.13 – 169.36 Mb Chr 2: 69.42 – 69.59 Mb
PubMed search

2M0P

NM_004525

NM_001081088

NP_004516

NP_001074557.1
NP_001074557

Low density lipoprotein-related protein 2 also known as LRP2 or megalin is a protein which in humans is encoded by the LRP2 gene.

LRP2 is a multiligand binding receptor found in the plasma membrane of many absorptive epithelial cells. LRP2 is a member of a family of receptors with structural similarities to the low density lipoprotein receptor (LDLR). LRP2 functions to mediate endocytosis of ligands leading to degradation in lysosomes or transcytosis. LRP2 (previously called glycoprotein 330) together with RAP (LRPAP1) forms the Heymann nephritis antigenic complex. LRP2 can also form complexes with cubilin: those complexes are able to reabsorb several molecules and can be inhibited by sodium maleate. LRP2 is expressed in epithelial cells of the thyroid (thyrocytes), where it can serve as a receptor for the protein thyroglobulin (Tg).


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Wikipedia

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