LDLR

LDLR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AJJ, 1D2J, 1F5Y, 1HJ7, 1HZ8, 1I0U, 1IJQ, 1LDL, 1LDR, 1N7D, 1XFE, 2FCW, 2KRI, 2LGP, 2W2M, 2W2N, 2W2O, 2W2P, 2W2Q, 3BPS, 3GCW, 3GCX, 3M0C, 3SO6, 2M7P, 2MG9, 3P5B, 3P5C, 4NE9
Identifiers
Aliases	LDLR, FH, FHC, LDLCQ2, low density lipoprotein receptor
External IDs	OMIM: 606945 MGI: 96765 HomoloGene: 55469 GeneCards: LDLR
Gene ontology Molecular function • calcium ion binding • clathrin heavy chain binding • virus receptor activity • glycoprotein binding • protease binding • protein binding • identical protein binding • very-low-density lipoprotein particle receptor activity • low-density lipoprotein receptor activity • low-density lipoprotein particle binding Cellular component • integral component of membrane • clathrin-coated endocytic vesicle membrane • endosome • late endosome • Golgi apparatus • membrane • receptor complex • plasma membrane • apical part of cell • integral component of plasma membrane • cell surface • basolateral plasma membrane • early endosome • low-density lipoprotein particle • clathrin-coated pit • lysosome • PCSK9-LDLR complex • endosome membrane • external side of plasma membrane • extracellular space • endolysosome membrane • sorting endosome Biological process • regulation of cholesterol homeostasis • positive regulation of triglyceride biosynthetic process • regulation of phosphatidylcholine catabolic process • steroid metabolic process • lipid transport • endocytosis • lipid metabolic process • phospholipid transport • cholesterol transport • cholesterol metabolic process • lipoprotein catabolic process • intestinal cholesterol absorption • transport • viral entry into host cell • cholesterol homeostasis • viral process • positive regulation of gene expression • positive regulation of inflammatory response • lipoprotein metabolic process • cellular response to fatty acid • negative regulation of gene expression • membrane organization • cholesterol import • cellular response to low-density lipoprotein particle stimulus • receptor-mediated endocytosis involved in cholesterol transport • chylomicron remnant clearance • low-density lipoprotein particle clearance Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3949	16835
Ensembl	ENSG00000130164	ENSMUSG00000032193
UniProt	P01130	P35951
RefSeq (mRNA)	NM_000527 NM_001195798 NM_001195799 NM_001195800 NM_001195802 NM_001195803	NM_001252658 NM_001252659 NM_010700
RefSeq (protein)	NP_000518 NP_001182727 NP_001182728 NP_001182729 NP_001182732	NP_001239587 NP_001239588 NP_034830
Location (UCSC)	Chr 19: 11.09 – 11.13 Mb	Chr 9: 21.72 – 21.75 Mb
PubMed search

1AJJ, 1D2J, 1F5Y, 1HJ7, 1HZ8, 1I0U, 1IJQ, 1LDL, 1LDR, 1N7D, 1XFE, 2FCW, 2KRI, 2LGP, 2W2M, 2W2N, 2W2O, 2W2P, 2W2Q, 3BPS, 3GCW, 3GCX, 3M0C, 3SO6, 2M7P, 2MG9, 3P5B, 3P5C, 4NE9

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