LRPAP1

LRPAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LRE, 1NRE, 1OP1, 1OV2, 2FCW, 2FTU, 2FYL, 2P01, 2P03
Identifiers
Aliases	LRPAP1, A2MRAP, A2RAP, HBP44, MRAP, MYP23, RAP, alpha-2-MRAP, LDL-receptor-related protein associated protein, LDL receptor related protein associated protein 1
External IDs	MGI: 96829 HomoloGene: 37612 GeneCards: LRPAP1
Gene location (Human) Chr. Chromosome 4 (human) Band 4p16.3 Start 3,506,376 bp End 3,532,559 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 B2|5 18.01 cM Start 35,091,501 bp End 35,105,766 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • lipase binding • very-low-density lipoprotein particle receptor binding • low-density lipoprotein particle receptor binding • protein binding • receptor binding • heparin binding • receptor antagonist activity Cellular component • cytoplasm • vesicle • cell surface • endoplasmic reticulum • rough endoplasmic reticulum • extracellular region • endosome • endoplasmic reticulum-Golgi intermediate compartment • Golgi apparatus • Golgi lumen • cis-Golgi network • plasma membrane • endosome lumen • rough endoplasmic reticulum lumen Biological process • negative regulation of protein binding • negative regulation of very-low-density lipoprotein particle clearance • negative regulation of amyloid-beta clearance • regulation of receptor-mediated endocytosis • extracellular negative regulation of signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4043	16976
Ensembl	ENSG00000163956	ENSMUSG00000029103
UniProt	P30533	P55302
RefSeq (mRNA)	NM_002337	NM_013587
RefSeq (protein)	NP_002328	NP_038615
Location (UCSC)	Chr 4: 3.51 – 3.53 Mb	Chr 4: 35.09 – 35.11 Mb
PubMed search

Alpha-2-MRAP_N
haddock model of the complex between double module of lrp, cr56, and first domain of receptor associated protein, rap-d1.
Identifiers
Symbol	Alpha-2-MRAP_N
Pfam	PF06400
InterPro	IPR009066
SCOP	1lre
SUPERFAMILY	1lre
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Alpha-2-MRAP_C
solution structure of domain 3 of rap
Identifiers
Symbol	Alpha-2-MRAP_C
Pfam	PF06401
InterPro	IPR010483
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

1LRE, 1NRE, 1OP1, 1OV2, 2FCW, 2FTU, 2FYL, 2P01, 2P03

4043

16976

ENSG00000163956

ENSMUSG00000029103

P30533

P55302

NM_002337

NM_013587

NP_002328

NP_038615

Low density lipoprotein receptor-related protein-associated protein 1 also known as LRPAP1 or RAP is a chaperone protein which in humans is encoded by the LRPAP1 gene.