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Cubilin

CUBN
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CUBN, IFCR, MGA1, gp280, cubilin
External IDs MGI: 1931256 HomoloGene: 37434 GeneCards: CUBN
RNA expression pattern
PBB GE CUBN 206775 at fs.png

PBB GE CUBN gnf1h06087 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001081

NM_001081084

RefSeq (protein)

NP_001072

NP_001074553

Location (UCSC) Chr 10: 16.82 – 17.13 Mb Chr 2: 13.28 – 13.49 Mb
PubMed search

3KQ4

NM_001081

NM_001081084

NP_001072

NP_001074553

Cubilin is a protein that in humans is encoded by the CUBN gene.

Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia. A complex of amnionless and cubilin forms the cubam receptor. It can be found in the proximal tubule forming part complexes with megalin; the function of these complexes is reabsorptive and can be inhibited by sodium maleate.



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