Cubilin

CUBN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KQ4
Identifiers
Aliases	CUBN, IFCR, MGA1, gp280, cubilin
External IDs	MGI: 1931256 HomoloGene: 37434 GeneCards: CUBN
Gene ontology Molecular function • calcium ion binding • protein homodimerization activity • protein binding • transporter activity • cobalamin binding • metal ion binding • receptor activity Cellular component • brush border • extrinsic component of external side of plasma membrane • endoplasmic reticulum • clathrin-coated pit • lysosomal membrane • cytoplasm • Golgi apparatus • endosome • brush border membrane • apical part of cell • lysosome • lysosomal lumen • membrane • cytosol • extracellular exosome • endocytic vesicle • apical plasma membrane • endosome membrane • plasma membrane Biological process • tissue homeostasis • cobalamin transport • lipid metabolic process • protein transport • cholesterol metabolic process • vitamin D metabolic process • cobalamin metabolic process • steroid metabolic process • endocytosis • lipoprotein transport • receptor-mediated endocytosis • high-density lipoprotein particle clearance • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8029	65969
Ensembl	ENSG00000107611	ENSMUSG00000026726
UniProt	O60494	Q9JLB4
RefSeq (mRNA)	NM_001081	NM_001081084
RefSeq (protein)	NP_001072	NP_001074553
Location (UCSC)	Chr 10: 16.82 – 17.13 Mb	Chr 2: 13.28 – 13.49 Mb
PubMed search

3KQ4

8029

65969

ENSG00000107611

ENSMUSG00000026726

O60494

Q9JLB4

NM_001081

NM_001081084

NP_001072

NP_001074553

Cubilin is a protein that in humans is encoded by the CUBN gene.

Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B₁₂ complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia. A complex of amnionless and cubilin forms the cubam receptor. It can be found in the proximal tubule forming part complexes with megalin; the function of these complexes is reabsorptive and can be inhibited by sodium maleate.

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Wikipedia