Amnionless

AMN
Identifiers
Aliases	AMN, PRO1028, amnionless, Amnionless, amnion associated transmembrane protein
External IDs	MGI: 1934943 HomoloGene: 12804 GeneCards: AMN
Gene ontology Molecular function • receptor binding Cellular component • extracellular exosome • endosome membrane • membrane • integral component of membrane • apical part of cell • clathrin-coated pit • endosome • apical plasma membrane • plasma membrane • extracellular space • endocytic vesicle • brush border membrane • protein complex Biological process • cobalamin metabolic process • multicellular organism development • protein localization • receptor-mediated endocytosis • cobalamin transport • Golgi to plasma membrane protein transport • excretion • protein transport • high-density lipoprotein particle clearance • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	81693	93835
Ensembl	ENSG00000166126	ENSMUSG00000021278
UniProt	Q9BXJ7	Q99JB7
RefSeq (mRNA)	NM_030943	NM_033603
RefSeq (protein)	NP_112205	NP_291081
Location (UCSC)	Chr 14: 102.92 – 102.93 Mb	Chr 12: 111.27 – 111.28 Mb
PubMed search

81693

93835

ENSG00000166126

ENSMUSG00000021278

Q9BXJ7

Q99JB7

NM_030943

NM_033603

NP_112205

NP_291081

Amnionless is a protein that in humans is encoded by the AMN gene.

A complex of amnionless and cubilin forms the cubam receptor.

The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila.

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