LMTK2

LMTK2
Identifiers
Aliases	LMTK2, AATYK2, BREK, KPI-2, KPI2, LMR2, PPP1R100, cprk, hBREK, lemur tyrosine kinase 2
External IDs	MGI: 3036247 HomoloGene: 8948 GeneCards: LMTK2
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • kinase activity • myosin VI binding • protein serine/threonine kinase activity • protein binding • protein phosphatase inhibitor activity • ATP binding Cellular component • integral component of membrane • recycling endosome • Golgi apparatus • membrane • early endosome • perinuclear region of cytoplasm • cytosol • growth cone • neuronal cell body Biological process • transferrin transport • phosphorylation • protein phosphorylation • early endosome to late endosome transport • receptor recycling • peptidyl-serine phosphorylation • endocytic recycling • protein autophosphorylation • peptidyl-threonine phosphorylation • negative regulation of catalytic activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22853	231876
Ensembl	ENSG00000164715	ENSMUSG00000038970
UniProt	Q8IWU2	Q3TYD6
RefSeq (mRNA)	NM_014916	NM_001081109
RefSeq (protein)	NP_055731	NP_001074578
Location (UCSC)	Chr 7: 98.11 – 98.21 Mb	Chr 5: 144.1 – 144.19 Mb
PubMed search

22853

231876

ENSG00000164715

ENSMUSG00000038970

Q8IWU2

Q3TYD6

NM_014916

NM_001081109

NP_055731

NP_001074578

Serine/threonine-protein kinase LMTK2 also known as Lemur tyrosine kinase 2 (LMTK2) is an enzyme that in humans is encoded by the LMTK2 gene.

The LMTK2 enzyme belongs to both the protein kinase and the tyrosine kinase families. It contains N-terminus transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as androgen receptor, inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosphorylates other proteins, and is itself also phosphorylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein is involved in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis.

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