Nerve growth factor

NGF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ZBN, 1SG1, 1WWW, 2IFG, 4EDW, 4EDX
Identifiers
Aliases	NGF, Beta-HSAN5, NGFB, nerve growth factor
External IDs	OMIM: 162030 MGI: 97321 HomoloGene: 1876 GeneCards: NGF
Gene ontology Molecular function • peptidase inhibitor activity • enzyme inhibitor activity • protein binding • metalloendopeptidase inhibitor activity • nerve growth factor receptor binding • growth factor activity • receptor binding Cellular component • endosome • Golgi lumen • extracellular region • cytoplasmic vesicle Biological process • negative regulation of neuron apoptotic process • regulation of neuron differentiation • neuron projection morphogenesis • negative regulation of peptidase activity • neurotrophin TRK receptor signaling pathway • activation of MAPKK activity • cell-cell signaling • negative regulation of apoptotic process • regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of axonogenesis • positive regulation of gene expression • positive regulation of apoptotic process • nerve growth factor processing • extrinsic apoptotic signaling pathway via death domain receptors • phosphatidylinositol-mediated signaling • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • microtubule-based movement • activation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of Ras protein signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4803	18049
Ensembl	ENSG00000134259	ENSMUSG00000027859
UniProt	P01138	P01139
RefSeq (mRNA)	NM_002506	NM_001112698 NM_013609
RefSeq (protein)	NP_002497	NP_001106168.1 NP_038637.1 NP_001106168 NP_038637
Location (UCSC)	Chr 1: 115.29 – 115.34 Mb	Chr 3: 102.47 – 102.52 Mb
PubMed search

4ZBN, 1SG1, 1WWW, 2IFG, 4EDW, 4EDX

4803

18049

ENSG00000134259

ENSMUSG00000027859

P01138

P01139

NM_002506

NM_001112698
NM_013609

NP_002497

NP_001106168.1
NP_038637.1
NP_001106168
NP_038637

Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is perhaps the prototypical growth factor, in that it was one of the first to be described. Since it was first isolated by Nobel Laureates Rita Levi-Montalcini and Stanley Cohen in 1956, numerous biological processes involving NGF have been identified, two of them being the survival of pancreatic beta cells and the regulation of the immune system.

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Wikipedia