CDK5R1

CDK5R1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H4L, 1UNG, 1UNH, 1UNL, 3O0G
Identifiers
Aliases	CDK5R1, CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a, cyclin-dependent kinase 5, regulatory subunit 1 (p35), cyclin dependent kinase 5 regulatory subunit 1
External IDs	MGI: 101764 HomoloGene: 31200 GeneCards: CDK5R1
Gene ontology Molecular function • protein kinase activity • calcium ion binding • ephrin receptor binding • cadherin binding • cyclin-dependent protein kinase 5 activator activity • kinase activity • protein binding • protein kinase binding • protein serine/threonine kinase activator activity Cellular component • cytoplasm • cytosol • membrane • postsynaptic density • intracellular membrane-bounded organelle • growth cone • neuromuscular junction • dendritic spine • axon • neuronal cell body • dendrite • cyclin-dependent protein kinase 5 holoenzyme complex • perinuclear region of cytoplasm • contractile fiber • nucleus • nucleoplasm • plasma membrane Biological process • positive regulation of protein kinase activity • regulation of neuron differentiation • G-protein coupled acetylcholine receptor signaling pathway • regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of actin cytoskeleton organization • embryo development • rhythmic process • ephrin receptor signaling pathway • neuron cell-cell adhesion • regulation of microtubule cytoskeleton organization • neuron migration • cerebellum development • positive regulation of protein serine/threonine kinase activity • positive regulation of neuron apoptotic process • brain development • ionotropic glutamate receptor signaling pathway • layer formation in cerebral cortex • peptidyl-serine phosphorylation • neuron differentiation • cell proliferation • peptidyl-threonine phosphorylation • negative regulation of transcription, DNA-templated • neuron projection development • cerebral cortex radially oriented cell migration • axonal fasciculation • hippocampus development • negative regulation of axon extension • regulation of dendritic spine morphogenesis • regulation of macroautophagy • superior olivary nucleus maturation • positive regulation of cell cycle arrest • positive regulation of protein targeting to membrane • axon guidance • regulation of signal transduction by p53 class mediator • serine phosphorylation of STAT protein Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8851	12569
Ensembl	ENSG00000176749	ENSMUSG00000048895
UniProt	Q15078	P61809
RefSeq (mRNA)	NM_003885	NM_009871
RefSeq (protein)	NP_003876	NP_034001.1 NP_034001
Location (UCSC)	Chr 17: 32.49 – 32.49 Mb	Chr 11: 80.48 – 80.48 Mb
PubMed search

1H4L, 1UNG, 1UNH, 1UNL, 3O0G

8851

12569

ENSG00000176749

ENSMUSG00000048895

Q15078

P61809

NM_003885

NM_009871

NP_003876

NP_034001.1
NP_034001

Cyclin-dependent kinase 5 activator 1 is an enzyme that in humans is encoded by the CDK5R1 gene.

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

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