Cyclin-dependent kinase 5

CDK5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H4L, 1UNG, 1UNH, 1UNL, 3O0G, 4AU8
Identifiers
Aliases	CDK5, Cdk5, AW048668, Crk6, LIS7, PSSALRE, cyclin-dependent kinase 5, cyclin dependent kinase 5
External IDs	MGI: 101765 HomoloGene: 3623 GeneCards: CDK5
Targeted by Drug
dinaciclib
Gene ontology Molecular function • acetylcholine receptor activator activity • kinase activity • cytoskeletal protein binding • ATP binding • protein kinase activity • protein serine/threonine kinase activity • ErbB-3 class receptor binding • transferase activity • ephrin receptor binding • tau-protein kinase activity • protein binding • protein kinase binding • nucleotide binding • p53 binding • ErbB-2 class receptor binding • cyclin-dependent protein serine/threonine kinase activity Cellular component • postsynaptic membrane • membrane • synapse • cytoskeleton • cell projection • lamellipodium • perikaryon • filopodium • growth cone • neuromuscular junction • plasma membrane • axon • neuronal cell body • postsynaptic density • cell junction • dendrite • cyclin-dependent protein kinase 5 holoenzyme complex • presynapse • nucleoplasm • nucleus • cytoplasm • cytosol Biological process • synaptic transmission, glutamatergic • rhythmic process • negative regulation of cell cycle • oligodendrocyte differentiation • synaptic transmission, dopaminergic • protein phosphorylation • positive regulation of neuron apoptotic process • central nervous system neuron development • regulation of synaptic vesicle recycling • cell cycle • regulated exocytosis • corpus callosum development • cell proliferation • intracellular protein transport • neuron projection development • regulation of dendritic spine morphogenesis • negative regulation of synaptic plasticity • cerebellar cortex formation • exocytosis • response to cocaine • apoptotic process • regulation of apoptotic process • negative regulation of proteolysis • behavioral response to cocaine • synaptic vesicle exocytosis • receptor clustering • positive regulation of calcium ion-dependent exocytosis • telencephalon development • synaptic vesicle endocytosis • response to wounding • regulation of postsynaptic membrane potential • excitatory postsynaptic potential • synapse assembly • protein autophosphorylation • positive regulation of actin cytoskeleton reorganization • negative regulation of neuron death • chemical synaptic transmission • neuron apoptotic process • neuron projection morphogenesis • associative learning • dendrite morphogenesis • phosphorylation • calcium ion import • Schwann cell development • neuron migration • cerebellum development • nervous system development • regulation of synaptic plasticity • neuron differentiation • cerebral cortex development • axon extension • sensory perception of pain • positive regulation of protein binding • cell-matrix adhesion • peptidyl-threonine phosphorylation • negative regulation of transcription, DNA-templated • negative regulation of axon extension • cortical actin cytoskeleton organization • regulation of cell cycle arrest • protein localization to synapse • positive regulation of protein targeting to membrane • positive regulation of protein kinase activity • visual learning • regulation of cell migration • axonogenesis • positive regulation of neuron death • receptor catabolic process • cell division • negative regulation of protein ubiquitination • positive regulation of receptor activity • negative regulation of protein export from nucleus • layer formation in cerebral cortex • peptidyl-serine phosphorylation • nucleocytoplasmic transport • cerebellar cortex development • forebrain development • motor neuron axon guidance • cell migration • skeletal muscle tissue development • hippocampus development • regulation of macroautophagy • regulation of signal transduction by p53 class mediator • serine phosphorylation of STAT protein Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1020	12568
Ensembl	ENSG00000164885	ENSMUSG00000028969
UniProt	Q00535	P49615
RefSeq (mRNA)	NM_001164410 NM_004935	NM_007668
RefSeq (protein)	NP_001157882 NP_004926	NP_031694.1 NP_031694
Location (UCSC)	Chr 7: 151.05 – 151.06 Mb	Chr 5: 24.42 – 24.42 Mb
PubMed search

1H4L, 1UNG, 1UNH, 1UNL, 3O0G, 4AU8

1020

12568

ENSG00000164885

ENSMUSG00000028969

Q00535

P49615

NM_001164410
NM_004935

NM_007668

NP_001157882
NP_004926

NP_031694.1
NP_031694

Cell division protein kinase 5 is an enzyme that in humans is encoded by the CDK5 gene. The protein encoded by this gene is part of the cyclin-dependent kinase family.

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