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Italian War of 1521–1526

Italian War of 1521–26
Part of the Italian Wars
Battle of Pavia, oil on panel.jpg
The Battle of Pavia by an unknown Flemish artist (oil on panel, 16th century)
Date 1521–26
Location Italy, France, and Spain
Result Imperial–Spanish victory
Belligerents

 France

 Republic of Venice

 Holy Roman Empire
Spain Spain
 England

 Papal States
Commanders and leaders
Kingdom of France Francis I  (POW)
Kingdom of France Vicomte de Lautrec
Kingdom of France Guillaume de Bonnivet 
Kingdom of France Pierre de Bayard 
Holy Roman Empire Spain Charles V
Holy Roman Empire Spain Charles de Lannoy
Holy Roman Empire Spain Marquis of Pescara
Holy Roman Empire Spain Duke of Bourbon
Holy Roman Empire Franz von Sickingen
Holy Roman Empire Georg von Frundsberg
Kingdom of England Duke of Suffolk
Papal States Prospero Colonna

 France

 Holy Roman Empire
Spain Spain
 England

The Italian War of 1521–26, sometimes known as the Four Years' War, was a part of the Italian Wars. The war pitted Francis I of France and the Republic of Venice against the Holy Roman Emperor Charles V, Henry VIII of England, and the Papal States. The conflict arose from animosity over the election of Charles as Emperor in 1519–20 and from Pope Leo X's need to ally with Charles against Martin Luther.


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