Charles de Lannoy (c. 1487 – 23 September 1527) was a soldier and statesman from the Low Countries in service of the Habsburg Emperors Maximilian I and Charles V.
He was a member of the noble de Lannoy family. Charles de Lannoy was born the younger son of Jean de Lannoy, Lord of Mingoval, himself nephew of Jean III de Lannoy. His mother was Philipotte de Lalaing (c. 1487). He took service with the Emperor Maximilian I and won distinction for bravery and leadership. He was appointed member to the council of Charles of Burgundy; later Emperor Charles V and his Caballerizo mayor in 1515. He was appointed knight of the Order of the Golden Fleece in 1516. He became governor of Tournai in 1521, was made viceroi of Naples in 1522 and made commander in chief of Imperial armies in Italy upon the death of Prospero Colonna at the end of 1523.
His main experience in that era's warfare consisted chiefly of the Italian War of 1521 and the War of the League of Cognac. He commanded the Battle of the Sesia (1524), and the siege of Marseille (1524) and Pavia (1525).
In 1526 he became the first count of Lannoy and Mayordomo mayor to the Emperor.