Italian War of 1521

Italian War of 1521–26
Part of the Italian Wars
The Battle of Pavia by an unknown Flemish artist (oil on panel, 16th century)
Date 1521–26 Location Italy, France, and Spain Result Imperial–Spanish victory
Belligerents
France Swiss mercenaries  Republic of Venice	Holy Roman Empire Spain  England  Papal States
Commanders and leaders
Francis I  (POW) Vicomte de Lautrec Guillaume de Bonnivet † Pierre de Bayard †	Charles V Charles de Lannoy Marquis of Pescara Duke of Bourbon Franz von Sickingen Georg von Frundsberg Duke of Suffolk Prospero Colonna

 France

 Holy Roman Empire
Spain
 England

The Italian War of 1521–26, sometimes known as the Four Years' War, was a part of the Italian Wars. The war pitted Francis I of France and the Republic of Venice against the Holy Roman Emperor Charles V, Henry VIII of England, and the Papal States. The conflict arose from animosity over the election of Charles as Emperor in 1519–20 and from Pope Leo X's need to ally with Charles against Martin Luther.

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