Insulin-like growth factor binding protein 3

IGFBP3
Identifiers
Aliases	IGFBP3, BP-53, IBP3, insulin like growth factor binding protein 3
External IDs	MGI: 96438 HomoloGene: 500 GeneCards: IGFBP3
Gene ontology Molecular function • fibronectin binding • insulin-like growth factor binding • protein tyrosine phosphatase activator activity • growth factor binding • insulin-like growth factor I binding • metal ion binding • insulin-like growth factor II binding • protein binding Cellular component • insulin-like growth factor ternary complex • extracellular region • insulin-like growth factor binding protein complex • extracellular exosome • nucleus • extracellular space • endoplasmic reticulum lumen Biological process • negative regulation of protein phosphorylation • cellular protein metabolic process • negative regulation of smooth muscle cell proliferation • negative regulation of smooth muscle cell migration • protein phosphorylation • regulation of insulin-like growth factor receptor signaling pathway • regulation of glucose metabolic process • positive regulation of insulin-like growth factor receptor signaling pathway • positive regulation of myoblast differentiation • regulation of cell growth • osteoblast differentiation • positive regulation of apoptotic process • regulation of growth • negative regulation of signal transduction • type B pancreatic cell proliferation • positive regulation of MAPK cascade • negative regulation of cell proliferation • apoptotic process • positive regulation of catalytic activity • regulation of apoptotic process • post-translational protein modification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3486	16009
Ensembl	ENSG00000146674	ENSMUSG00000020427
UniProt	P17936	P47878
RefSeq (mRNA)	NM_001013398 NM_000598	NM_008343
RefSeq (protein)	NP_000589 NP_001013416	NP_032369
Location (UCSC)	Chr 7: 45.91 – 45.92 Mb	Chr 11: 7.21 – 7.21 Mb
PubMed search

3486

16009

ENSG00000146674

ENSMUSG00000020427

P17936

P47878

NM_001013398
NM_000598

NM_008343

NP_000589
NP_001013416

NP_032369

Insulin-like growth factor-binding protein 3, also known as IGFBP-3, is a protein that in humans is encoded by the IGFBP3 gene. IGFBP-3 is one of six IGF binding proteins (IGFBP-1 to IGFBP-6) that have highly conserved structures and bind the insulin-like growth factors IGF-1 and IGF-2 with high affinity. IGFBP-7, sometimes inappropriately included in this family, shares neither the conserved structural features nor the high IGF affinity.

IGFBP-3 was first isolated, characterized, and quantitated in human plasma, in 1986. It has well-documented functions in the circulation, in the extracellular environment, and inside cells. It is the main IGF transport protein in the bloodstream, where it carries the growth factors predominantly in stable complexes that contain the binding protein, either IGF-1 or IGF-2, and a third protein called the acid-labile subunit or ALS.

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Wikipedia