IGFBP7

IGFBP7
Identifiers
Aliases	IGFBP7, AGM, FSTL2, IBP-7, IGFBP-7, IGFBP-7v, IGFBPRP1, MAC25, PSF, RAMSVPS, TAF, insulin like growth factor binding protein 7
External IDs	MGI: 1352480 HomoloGene: 1193 GeneCards: IGFBP7
Gene ontology Molecular function • protein binding • growth factor binding • insulin-like growth factor binding Cellular component • extracellular region • extracellular matrix • extracellular exosome • extracellular space Biological process • regulation of cell growth • negative regulation of cell proliferation • cell adhesion • response to retinoic acid • cellular response to hormone stimulus • regulation of steroid biosynthetic process • response to heat • embryo implantation • response to organic cyclic compound • response to cortisol Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3490	29817
Ensembl	ENSG00000163453	ENSMUSG00000036256
UniProt	Q16270	Q61581
RefSeq (mRNA)	NM_001553 NM_001253835	NM_001159518 NM_008048
RefSeq (protein)	NP_001240764 NP_001544	NP_032074.3 NP_001152990 NP_032074
Location (UCSC)	Chr 4: 57.03 – 57.11 Mb	Chr 5: 77.35 – 77.41 Mb
PubMed search

3490

29817

ENSG00000163453

ENSMUSG00000036256

Q16270

Q61581

NM_001553
NM_001253835

NM_001159518
NM_008048

NP_001240764
NP_001544

NP_032074.3
NP_001152990
NP_032074

Insulin-like growth factor-binding protein 7 is a protein that in humans is encoded by the IGFBP7 gene. The major function of the protein is the regulation of availability of insulin-like growth factors (IGFs) in tissue as well as in modulating IGF binding to its receptors. IGFBP7 binds to IGF with high affinity. It also stimulates cell adhesion. The protein is implicated in some cancers.

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Wikipedia