IGFBP1

IGFBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZT3, 1ZT5, 2DSQ
Identifiers
Aliases	IGFBP1, AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1, insulin like growth factor binding protein 1
External IDs	MGI: 96436 HomoloGene: 498 GeneCards: IGFBP1
Gene ontology Molecular function • receptor binding • insulin-like growth factor II binding • insulin-like growth factor binding • growth factor binding • insulin-like growth factor I binding Cellular component • extracellular region • Golgi apparatus • extracellular space Biological process • PERK-mediated unfolded protein response • tissue regeneration • insulin receptor signaling pathway • regulation of cell growth • negative regulation of canonical Wnt signaling pathway • signal transduction • regulation of insulin-like growth factor receptor signaling pathway • cellular protein metabolic process • positive regulation of cell growth • aging Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3484	16006
Ensembl	ENSG00000146678	ENSMUSG00000020429
UniProt	P08833	P47876
RefSeq (mRNA)	NM_001013029 NM_000596	NM_008341
RefSeq (protein)	NP_000587	NP_032367.3 NP_032367
Location (UCSC)	Chr 7: 45.89 – 45.89 Mb	Chr 11: 7.2 – 7.2 Mb
PubMed search

1ZT3, 1ZT5, 2DSQ

3484

16006

ENSG00000146678

ENSMUSG00000020429

P08833

P47876

NM_001013029
NM_000596

NM_008341

NP_000587

NP_032367.3
NP_032367

Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a protein that in humans is encoded by the IGFBP1 gene.

This gene is a member of the Insulin-like growth factor-binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a type-I thyroglobulin domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

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Wikipedia