IGFALS

IGFALS
Identifiers
Aliases	IGFALS, ALS, ACLSD, insulin like growth factor binding protein acid labile subunit
External IDs	MGI: 107973 HomoloGene: 37987 GeneCards: IGFALS
Gene location (Human) Chr. Chromosome 16 (human) Band 16p13.3 Start 1,790,413 bp End 1,794,971 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 A3.3|17 12.53 cM Start 24,878,770 bp End 24,882,008 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • insulin-like growth factor binding Cellular component • extracellular region • insulin-like growth factor ternary complex • extracellular exosome • nucleoplasm • extracellular space Biological process • cellular protein metabolic process • cell adhesion • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3483	16005
Ensembl	ENSG00000099769	ENSMUSG00000046070
UniProt	P35858	P70389
RefSeq (mRNA)	NM_001146006 NM_004970	NM_008340
RefSeq (protein)	NP_001139478 NP_004961	NP_032366
Location (UCSC)	Chr 16: 1.79 – 1.79 Mb	Chr 16: 24.88 – 24.88 Mb
PubMed search

3483

16005

ENSG00000099769

ENSMUSG00000046070

P35858

P70389

NM_001146006
NM_004970

NM_008340

NP_001139478
NP_004961

NP_032366

Insulin-like growth factor binding protein, acid labile subunit, also known as IGFALS, is a protein which in humans is encoded by the IGFALS gene.

The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Three transcript variants encoding two different isoforms have been found for this gene.

Defects in this gene are a cause of acid-labile subunit deficiency, which manifests itself in a delayed and slow puberty.

IGFALS has been shown to interact with IGFBP3.

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Wikipedia