IGFBP3

IGFBP3
Identifiers
Aliases	IGFBP3, BP-53, IBP3, insulin like growth factor binding protein 3
External IDs	MGI: 96438 HomoloGene: 500 GeneCards: IGFBP3
Gene ontology Molecular function • fibronectin binding • insulin-like growth factor binding • protein tyrosine phosphatase activator activity • growth factor binding • insulin-like growth factor I binding • metal ion binding • insulin-like growth factor II binding • protein binding Cellular component • insulin-like growth factor ternary complex • extracellular region • insulin-like growth factor binding protein complex • extracellular exosome • nucleus • extracellular space • endoplasmic reticulum lumen Biological process • negative regulation of protein phosphorylation • cellular protein metabolic process • negative regulation of smooth muscle cell proliferation • negative regulation of smooth muscle cell migration • protein phosphorylation • regulation of insulin-like growth factor receptor signaling pathway • regulation of glucose metabolic process • positive regulation of insulin-like growth factor receptor signaling pathway • positive regulation of myoblast differentiation • regulation of cell growth • osteoblast differentiation • positive regulation of apoptotic process • regulation of growth • negative regulation of signal transduction • type B pancreatic cell proliferation • positive regulation of MAPK cascade • negative regulation of cell proliferation • apoptotic process • positive regulation of catalytic activity • regulation of apoptotic process • post-translational protein modification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3486	16009
Ensembl	ENSG00000146674	ENSMUSG00000020427
UniProt	P17936	P47878
RefSeq (mRNA)	NM_001013398 NM_000598	NM_008343
RefSeq (protein)	NP_000589 NP_001013416	NP_032369.2 NP_032369
Location (UCSC)	Chr 7: 45.91 – 45.92 Mb	Chr 11: 7.21 – 7.21 Mb
PubMed search

3486

16009

ENSG00000146674

ENSMUSG00000020427

P17936

P47878

NM_001013398
NM_000598

NM_008343

NP_000589
NP_001013416

NP_032369.2
NP_032369

Insulin-like growth factor-binding protein 3, also known as IGFBP-3, is a protein that in humans is encoded by the IGFBP3 gene. IGFBP-3 is one of six IGF binding proteins (IGFBP-1 to IGFBP-6) that have highly conserved structures and bind the insulin-like growth factors IGF-1 and IGF-2 with high affinity. IGFBP-7, sometimes inappropriately included in this family, shares neither the conserved structural features nor the high IGF affinity.

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