Infante Enrique, 1st Duke of Seville (Spanish: Infante Enrique María Fernando Carlos Francisco Luis de Borbón y Borbón-Dos Sicilias, Duque de Sevilla; 17 April 1823 – 12 March 1870), was an Infante of Spain and a member of the Spanish branch of the House of Bourbon. He was the grandson of Charles IV of Spain and became the first Duke of Seville in 1823. He was known for his progressive, even revolutionary, ideas during the reign of his double first cousin and sister-in-law, Isabella II of Spain.

Infante Enrique was born at Seville, Spain, the fourth child and second son of Infante Francisco de Paula of Spain (1794–1865; son of Charles IV of Spain and Princess Maria Luisa of Parma) and his wife, Princess Luisa Carlotta of Naples and Sicily (1804–1844), who was the daughter of Francis I of the Two Sicilies and Infanta María Isabella of Spain.

Born in the Andalusian city of Seville, his uncle King Ferdinand VII granted him the title of Duke of Seville in 1823. Ferdinand VII had conferred the title of Duke of Cádiz on Infante Francisco de Paula's first son Francisco de Asís in 1820 and then, after the child's death the following year, on Infante Francisco de Paula's next son, Francis. Enrique was baptized with the name Enrique María Fernando Carlos Francisco Luís and his godparents were his maternal aunt, Princess Marie Caroline, Duchess of Berry, and her son, the Duke of Bordeaux, for whom he was named.

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