IL12A

IL12A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1F45, 3HMX
Identifiers
Aliases	IL12A, CLMF, IL-12A, NFSK, NKSF1, P35, interleukin 12A
External IDs	MGI: 96539 HomoloGene: 681 GeneCards: IL12A
Gene ontology Molecular function • cytokine activity • interleukin-27 binding • interleukin-12 beta subunit binding • protein binding • protein heterodimerization activity • growth factor activity • interleukin-12 receptor binding Cellular component • cytoplasm • interleukin-12 complex • extracellular region • extracellular space • endoplasmic reticulum lumen Biological process • positive regulation of T cell differentiation • cellular response to virus • negative regulation of smooth muscle cell proliferation • extrinsic apoptotic signaling pathway • positive regulation of smooth muscle cell apoptotic process • response to virus • positive regulation of T cell mediated cytotoxicity • positive regulation of interferon-gamma production • positive regulation of natural killer cell activation • positive regulation of NK T cell activation • response to lipopolysaccharide • positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target • cell cycle arrest • immune response • response to UV-B • cellular response to lipopolysaccharide • negative regulation of interleukin-17 production • cell migration • positive regulation of natural killer cell mediated cytotoxicity • positive regulation of lymphocyte proliferation • positive regulation of dendritic cell chemotaxis • positive regulation of mononuclear cell proliferation • positive regulation of cell adhesion • defense response to protozoan • defense response to Gram-positive bacterium • positive regulation of T cell proliferation • positive regulation of tyrosine phosphorylation of STAT protein Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3592	16159
Ensembl	ENSG00000168811	ENSMUSG00000027776
UniProt	P29459	P43431
RefSeq (mRNA)	NM_000882	NM_001159424 NM_008351
RefSeq (protein)	NP_000873	NP_001152896.1 NP_032377.1 NP_001152896 NP_032377
Location (UCSC)	Chr 3: 159.99 – 160 Mb	Chr 3: 68.69 – 68.7 Mb
PubMed search

1F45, 3HMX

3592

16159

ENSG00000168811

ENSMUSG00000027776

P29459

P43431

NM_000882

NM_001159424
NM_008351

NP_000873

NP_001152896.1
NP_032377.1
NP_001152896
NP_032377

Interleukin-12 subunit alpha (IL-12 p35) is a protein that in humans is encoded by the IL12A gene.

This gene encodes a subunit of the cytokine Interleukin 12 (IL-12) that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-dependent induction of interferon gamma (INF-γ), and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.

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