NOS2A

NOS2

PDB 1nsi EBI.jpg

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1NSI, 2LL6, 2NSI, 3E7G, 3EJ8, 3HR4, 4CX7, 4NOS

Identifiers

NOS2, HEP-NOS, INOS, NOS, NOS2A, Nitric oxide synthase 2

External IDs

MGI: 97361 HomoloGene: 55473 GeneCards: NOS2

Gene location (Human)

Chr.	Chromosome 17 (human)

Band	17q11.2	Start	27,756,766 bp
Band	17q11.2	End	27,800,499 bp

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)

Band	11 B5\|11 46.74 cM	Start	78,920,787 bp
Band	11 B5\|11 46.74 cM	End	78,960,254 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• FMN binding • protein homodimerization activity • flavin adenine dinucleotide binding • arginine binding • tetrahydrobiopterin binding • metal ion binding • calmodulin binding • protein binding • heme binding • oxidoreductase activity • receptor binding • nitric-oxide synthase activity • NADPH-hemoprotein reductase activity • iron ion binding • NADP binding
Cellular component	• cytoplasm • cytosol • cortical cytoskeleton • peroxisome • intracellular • perinuclear region of cytoplasm • nucleus
Biological process	• positive regulation of guanylate cyclase activity • response to hypoxia • nitric oxide biosynthetic process • positive regulation of leukocyte mediated cytotoxicity • response to bacterium • negative regulation of protein catabolic process • regulation of insulin secretion • negative regulation of blood pressure • regulation of cytokine production involved in inflammatory response • positive regulation of killing of cells of other organism • negative regulation of gene expression • cell redox homeostasis • arginine catabolic process • prostaglandin secretion • interleukin-6 secretion • response to lipopolysaccharide • cellular response to drug • innate immune response in mucosa • regulation of cell proliferation • peptidyl-cysteine S-nitrosylation • defense response to bacterium • circadian rhythm • defense response to Gram-negative bacterium • nitric oxide mediated signal transduction • interleukin-8 secretion • cellular response to interferon-gamma • regulation of cellular respiration • cellular response to lipopolysaccharide • oxidation-reduction process • superoxide metabolic process • positive regulation of blood vessel diameter
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


4843


18126


ENSG00000007171


ENSMUSG00000020826


P35228


P29477

RefSeq (mRNA)


NM_000625 NM_153292


NM_010927 NM_001313921 NM_001313922

RefSeq (protein)


NP_000616


NP_001300850 NP_001300851 NP_035057

Location (UCSC)

Chr 17: 27.76 – 27.8 Mb

Chr 17: 78.92 – 78.96 Mb

PubMed search

1NSI, 2LL6, 2NSI, 3E7G, 3EJ8, 3HR4, 4CX7, 4NOS

ENSG00000007171

ENSMUSG00000020826

NM_000625
NM_153292

NM_010927
NM_001313921
NM_001313922

NP_001300850
NP_001300851
NP_035057

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Wikipedia

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