Huang was a teacher in Kuala Lumpur before leaving for Singapore. Huang moved to Singapore in the 1970s, close to penniless then, with only fifty dollars in hand. He joined the Singapore Broadcasting Corporation in 1977. He is perhaps best known for his appearance in The Awakening in which he played love interest to Xiang Yun's character and The Seletar Robbery during the 1980s. Huang is also known for starring alongside Chew Chor Meng the long-running popular series Don't Worry, Be Happy (1996–2002) and its spin-off Lobang King as the stingy uncle Leon Ong Kim Lye to Chew's character Ah Bee. Huang was nominated for and named one of the Top 10 Most Popular Male Artistes every single year in the annual Star Awards since its introduction in 1994, until his death in 2013. In total, Huang starred in more than a hundred Chinese-language television programmes. In addition to acting, Huang sang pieces for a few television sitcoms and also released two albums. He was an ambassador for anti-ageing product company Zell-V. He was an actor for MediaCorp from the late 1970s until his death. Appearing in more than 100 television programmes, he was among the first few batches of locally trained actors to enter the local entertainment industry and considered to be one of the "pioneers in local Chinese drama". Huang died on 20 April 2013 of lymphoma, a cancer of the blood. Reactions to his death were reported to have "flooded the Internet".

Huang gained Singaporean citizenship in October 2008 after residing in the country for 27 years. Huang was married with two children: a son and a daughter. He was a "lifelong devotee" of Buddhism.

There was public concern after Huang appeared visibly haggard during MediaCorp Channel 8's 30th Drama Anniversary Show. He clarified that he had been suffering from stomach flu, said to have been contracted in September 2012. During which, he was estimated to have lost 6–7 kilograms in weight. Huang would also experience intervals of severe fever. In November 2012, Huang was diagnosed with lymphoma and had to go for chemotherapy. His condition was not disclosed to the general public until his death, because Huang "wanted to go through this by himself".

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