HRH3
HRH3 |
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Identifiers |
Aliases |
HRH3, GPCR97, HH3R, histamine receptor H3 |
External IDs |
MGI: 2139279 HomoloGene: 5232 GeneCards: HRH3 |
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Targeted by Drug |
dimaprit, histamine, imetit, Immepip, Immethridine, Impentamine, methimepip, proxyfan, , impromidine, ciproxifan, clobenpropit, conessine, jnj-5207852, pitolisant, thioperamide, abt-239
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) |
Chr 20: 62.21 – 62.22 Mb |
Chr 2: 180.1 – 180.1 Mb |
PubMed search |
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11255
99296
ENSG00000101180
ENSMUSG00000039059
Q9Y5N1
P58406
NM_007232
NM_133849
NP_009163
NP_598610.1
NP_598610
Histamine H3 receptors are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where they act as autoreceptors in presynaptic histaminergic neurons, and also control histamine turnover by feedback inhibition of histamine synthesis and release. The H3 receptor has also been shown to presynaptically inhibit the release of a number of other neurotransmitters (i.e. it acts as an inhibitory heteroreceptor) including, but probably not limited to dopamine, GABA, acetylcholine, noradrenaline, histamine and serotonin.
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