Thioperamide

Thioperamide

Clinical data
ATC code	none
Identifiers
IUPAC name N-Cyclohexyl-4-(1H-imidazol-4-yl)piperidine-1-carbothioamide
CAS Number	106243-16-7 N
PubChem CID	3035905
IUPHAR/BPS	1267
ChemSpider	2300031 Y
UNII	II4319BWUI
ChEMBL	CHEMBL260374 Y
Chemical and physical data
Formula	C15H24N4S
Molar mass	292.44 g/mol
3D model (Jmol)	Interactive image
SMILES S=C(N2CCC(c1cncn1)CC2)NC3CCCCC3
InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20) Y Key:QKDDJDBFONZGBW-UHFFFAOYSA-N Y
NY (what is this?)

Thioperamide is a potent HRH₄ antagonist and selective HRH₃ antagonist capable of crossing the blood–brain barrier. It was used by Jean-Charles Schwartz in his early experiments regarding the H₃ receptor. Thioperamide was found to be an antagonist of histamine autoreceptors, which negatively regulate the release of histamine, and enhances the activity of histaminergic neurons by blocking autoreceptors, leading to greater release of histamine.