HK2

HK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NZT, 5HFU, 5HG1, 5HEX
Identifiers
Aliases	HK2, HKII, HXK2, hexokinase 2
External IDs	MGI: 1315197 HomoloGene: 37273 GeneCards: HK2
Gene location (Human) Chr. Chromosome 2 (human) Band 2p12 Start 74,833,981 bp End 74,893,359 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band n/a Start 82,725,025 bp End 82,774,454 bp
Gene ontology Molecular function • transferase activity • nucleotide binding • mannokinase activity • hexokinase activity • phosphotransferase activity, alcohol group as acceptor • kinase activity • glucose binding • catalytic activity • protein binding • fructokinase activity • ATP binding • glucokinase activity Cellular component • cytosol • membrane • mitochondrial outer membrane • mitochondrion Biological process • phosphorylation • regulation of glucose import • canonical glycolysis • cellular glucose homeostasis • negative regulation of mitochondrial membrane permeability • carbohydrate phosphorylation • response to ischemia • maintenance of protein location in mitochondrion • establishment of protein localization to mitochondrion • apoptotic mitochondrial changes • negative regulation of reactive oxygen species metabolic process • hexose metabolic process • metabolic process • lactation • glycolytic process • Q14762260 • positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization • glucose metabolic process • glucose 6-phosphate metabolic process • cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3099	15277
Ensembl	ENSG00000159399	ENSMUSG00000000628
UniProt	P52789	O08528
RefSeq (mRNA)	NM_000189	NM_013820
RefSeq (protein)	NP_000180	NP_038848
Location (UCSC)	Chr 2: 74.83 – 74.89 Mb	Chr 2: 82.73 – 82.77 Mb
PubMed search

2NZT, 5HFU, 5HG1, 5HEX

3099

15277

ENSG00000159399

ENSMUSG00000000628

P52789

O08528

NM_000189

NM_013820

NP_000180

NP_038848

Hexokinase 2 also known as HK2 is an enzyme which in humans is encoded by the HK2 gene on chromosome 2.Hexokinases phosphorylate glucose to produce glucose-6-phosphate (G6P), the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the . Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009]

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