HDAC1

HDAC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BKX, 5ICN
Identifiers
Aliases	HDAC1, GON-10, HD1, RPD3, RPD3L1, histone deacetylase 1
External IDs	OMIM: 601241 MGI: 108086 HomoloGene: 68426 GeneCards: HDAC1
Targeted by Drug
abexinostat, apicidin, Belinostat, butyric acid, entinostat, givinostat, mocetinostat, panobinostat, pracinostat, quisinostat, resminostat, romidepsin, trichostatin A, valproic acid, vorinostat
Gene ontology Molecular function • RNA polymerase II distal enhancer sequence-specific DNA binding • NAD-dependent histone deacetylase activity (H3-K14 specific) • RNA polymerase II transcription corepressor activity • core promoter binding • RNA polymerase II transcription factor binding • histone deacetylase activity • protein N-terminus binding • transcription factor activity, sequence-specific DNA binding • protein deacetylase activity • histone deacetylase binding • activating transcription factor binding • transcription regulatory region sequence-specific DNA binding • NF-kappaB binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • deacetylase activity • protein binding • RNA polymerase II repressing transcription factor binding • nucleosomal DNA binding • enzyme binding • transcription regulatory region DNA binding • repressing transcription factor binding • hydrolase activity • transcription factor binding • chromatin binding • protein complex binding Cellular component • cytoplasm • NuRD complex • cytosol • histone deacetylase complex • Sin3 complex • nucleoplasm • nuclear chromatin • nucleus • perinuclear region of cytoplasm • neuron projection • chromatin • protein complex Biological process • hair follicle placode formation • epidermal cell differentiation • chromatin remodeling • regulation of transcription, DNA-templated • rhythmic process • negative regulation of androgen receptor signaling pathway • embryonic digit morphogenesis • positive regulation of receptor biosynthetic process • negative regulation of apoptotic process • blood coagulation • negative regulation of transcription from RNA polymerase II promoter • eyelid development in camera-type eye • circadian regulation of gene expression • negative regulation of gene expression • ATP-dependent chromatin remodeling • positive regulation of transcription, DNA-templated • odontogenesis of dentin-containing tooth • protein deacetylation • negative regulation by host of viral transcription • histone H4 deacetylation • fungiform papilla formation • negative regulation of myotube differentiation • viral process • histone deacetylation • negative regulation of canonical Wnt signaling pathway • positive regulation of transcription from RNA polymerase II promoter • positive regulation of tyrosine phosphorylation of Stat3 protein • response to amphetamine • histone H3 deacetylation • response to caffeine • transcription, DNA-templated • positive regulation of cell proliferation • positive regulation of type B pancreatic cell apoptotic process • negative regulation of cell proliferation • response to drug • regulation of signal transduction by p53 class mediator • positive regulation of oligodendrocyte differentiation • positive regulation of tumor necrosis factor production • positive regulation of interleukin-1 production • negative regulation of transcription, DNA-templated • methylation-dependent chromatin silencing • beta-catenin-TCF complex assembly • negative regulation of insulin secretion • response to hyperoxia • positive regulation of chemokine (C-X-C motif) ligand 2 production • covalent chromatin modification • response to lipopolysaccharide • negative regulation of peptidyl-lysine acetylation • cellular response to tumor necrosis factor • cellular response to oxidative stress • chromatin modification • negative regulation of neuron apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3065	433759
Ensembl	ENSG00000116478	ENSMUSG00000028800
UniProt	Q13547	O09106
RefSeq (mRNA)	NM_004964	NM_008228
RefSeq (protein)	NP_004955	NP_032254.1 NP_032254
Location (UCSC)	Chr 1: 32.29 – 32.33 Mb	Chr 4: 129.52 – 129.54 Mb
PubMed search

4BKX, 5ICN

3065

433759

ENSG00000116478

ENSMUSG00000028800

Q13547

O09106

NM_004964

NM_008228

NP_004955

NP_032254.1
NP_032254

Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.

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