HBG2

HBG2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FDH, 4MQJ, 4MQK
Identifiers
Aliases	HBG2, HBG-T1, TNCY, hemoglobin subunit gamma 2
External IDs	MGI: 96027 HomoloGene: 128032 GeneCards: HBG2
Gene ontology Molecular function • iron ion binding • oxygen transporter activity • heme binding • metal ion binding • oxygen binding • protein binding Cellular component • blood microparticle • hemoglobin complex • cytosol Biological process • oxygen transport • blood coagulation • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3048	15135
Ensembl	ENSG00000196565	ENSMUSG00000052187
UniProt	P69892	P02104
RefSeq (mRNA)	NM_000184	NM_008221
RefSeq (protein)	NP_000175	NP_032247
Location (UCSC)	Chr 11: 5.25 – 5.65 Mb	Chr 7: 103.85 – 103.85 Mb
PubMed search

1FDH, 4MQJ, 4MQK

3048

15135

ENSG00000196565

ENSMUSG00000052187

P69892

P02104

NM_000184

NM_008221

NP_000175

NP_032247

Hemoglobin subunit gamma-2 is a protein that in humans is encoded by the HBG2 gene.

The gamma globin genes (HBG1 and HBG2, this gene) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.

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Wikipedia