HBE1

HBE1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A9W
Identifiers
Aliases	HBE1, HBE, hemoglobin subunit epsilon 1
External IDs	MGI: 96024 HomoloGene: 110794 GeneCards: HBE1
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.4 Start 5,268,345 bp End 5,505,617 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 E3|7 54.85 cM Start 103,841,637 bp End 103,843,164 bp
Gene ontology Molecular function • hemoglobin alpha binding • metal ion binding • heme binding • iron ion binding • oxygen binding • oxygen transporter activity • protein binding Cellular component • cytosol • blood microparticle • hemoglobin complex Biological process • protein heterooligomerization • blood coagulation • oxygen transport • response to organic cyclic compound • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3046	15132
Ensembl	ENSG00000213931	ENSMUSG00000052217
UniProt	P02100	P04444
RefSeq (mRNA)	NM_005330	NM_008219
RefSeq (protein)	NP_005321 NP_005321.1	NP_032245
Location (UCSC)	Chr 11: 5.27 – 5.51 Mb	Chr 11: 103.84 – 103.84 Mb
PubMed search

1A9W

3046

15132

ENSG00000213931

ENSMUSG00000052217

P02100

P04444

NM_005330

NM_008219

NP_005321
NP_005321.1

NP_032245

Hemoglobin subunit epsilon is a protein that in humans is encoded by the HBE1 gene.

The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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