HBG1

HBG1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1I3D, 1I3E
Identifiers
Aliases	HBG1, HBG-T2, HBGA, HBGR, HSGGL1, PRO2979, hemoglobin subunit gamma 1
External IDs	HomoloGene: 133561 GeneCards: HBG1
Gene ontology Molecular function • iron ion binding • oxygen binding • heme binding • metal ion binding • oxygen transporter activity Cellular component • hemoglobin complex • cytosol Biological process • blood coagulation • oxygen transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3047	n/a
Ensembl	ENSG00000213934	n/a
UniProt	P69891	n/a
RefSeq (mRNA)	NM_000559	n/a
RefSeq (protein)	NP_000550	n/a
Location (UCSC)	Chr 11: 5.25 – 5.25 Mb	n/a
PubMed search		n/a

1I3D, 1I3E

3047

n/a

ENSG00000213934

n/a

P69891

n/a

NM_000559

n/a

NP_000550

n/a

Hemoglobin subunit gamma-1 is a protein that in humans is encoded by the HBG1 gene.

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) in the year following birth. In the non-pathological condition known as hereditary persistence of fetal hemoglobin (HPFH), gamma globin expression is continued into adulthood. Also, in cases of beta-thalassemia and related conditions, gamma chain production may be maintained, possibly as a mechanism to compensate for the mutated beta-globin. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.

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