Galanin receptor

galanin receptor 1
Identifiers
Symbol	GALR1
Alt. symbols	GALNR1, GALNR
Entrez	2587
HUGO	4132
OMIM	600377
RefSeq	NM_001480
UniProt	P47211
Other data
Locus	Chr. 18 q23

galanin receptor 2
Identifiers
Symbol	GALR2
Entrez	8811
HUGO	4133
OMIM	603691
RefSeq	NM_003857
UniProt	O43603
Other data
Locus	Chr. 17 q25.3

galanin receptor 3
Identifiers
Symbol	GALR3
Entrez	8484
HUGO	4134
OMIM	603692
RefSeq	NM_003614
UniProt	O60755
Other data
Locus	Chr. 22 q12.2-13.1

The galanin receptor is a G protein-coupled receptor, or metabotropic receptor which binds galanin.

Galanin receptors can be found throughout the peripheral and central nervous systems and the endocrine system. So far three subtypes are known to exist: GAL-R1, GAL-R2, and GAL-R3. The specific function of each subtype remains to be fully elucidated, although as of 2009 great progress is currently being made in this respect with the generation of receptor subtype-specific knockout mice, and the first selective ligands for galanin receptor subtypes. Selective galanin agonists are anticonvulsant, while antagonists produce antidepressant and anxiolytic effects in animals, so either agonist or antagonist ligands for the galanin receptors may be potentially therapeutic compounds in humans.

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Wikipedia