Galanin receptor 1

GALR1

Identifiers

GALR1, GALNR, GALNR1, Galanin receptor 1

External IDs

MGI: 1096364 HomoloGene: 74396 GeneCards: GALR1

Gene ontology
Molecular function	• G-protein coupled receptor activity • neuropeptide binding • signal transducer activity • peptide hormone binding • galanin receptor activity • protein binding
Cellular component	• integral component of membrane • membrane • plasma membrane • integral component of plasma membrane
Biological process	• positive regulation of cortisol secretion • G-protein coupled receptor signaling pathway • negative regulation of adenylate cyclase activity • adenylate cyclase-activating G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • digestion • phospholipase C-activating G-protein coupled receptor signaling pathway • positive regulation of transcription from RNA polymerase II promoter • signal transduction • neuropeptide signaling pathway
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


2587


14427

Ensembl


ENSG00000166573


ENSMUSG00000024553

UniProt


P47211


P56479

RefSeq (mRNA)


NM_001480


NM_008082

RefSeq (protein)


NP_001471


NP_032108

Location (UCSC)

Chr 18: 77.25 – 77.28 Mb

Chr 18: 82.39 – 82.41 Mb

PubMed search

Galanin receptor 1 (GAL₁) is a G-protein coupled receptor encoded by the GALR1 gene.

The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-trans membrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the GI/GO family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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