GLUT-4

SLC2A4
Identifiers
Aliases	SLC2A4, GLUT4, solute carrier family 2 member 4
External IDs	OMIM: 138190 MGI: 95758 HomoloGene: 74381 GeneCards: SLC2A4
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.1 Start 7,281,667 bp End 7,288,257 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B3|11 42.93 cM Start 69,942,539 bp End 69,948,188 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • substrate-specific transmembrane transporter activity • transmembrane transporter activity • transporter activity • protein binding • D-glucose transmembrane transporter activity • glucose transmembrane transporter activity Cellular component • cytoplasm • integral component of membrane • multivesicular body • vesicle • cytosol • endosome • membrane • intracellular membrane-bounded organelle • vesicle membrane • T-tubule • insulin-responsive compartment • plasma membrane • integral component of plasma membrane • cell surface • perinuclear region of cytoplasm • membrane raft • sarcolemma • clathrin-coated pit • trans-Golgi network transport vesicle • extracellular exosome • cytoplasmic vesicle membrane • external side of plasma membrane • endomembrane system • clathrin-coated vesicle Biological process • glucose transmembrane transport • glucose homeostasis • cellular response to osmotic stress • brown fat cell differentiation • cellular response to insulin stimulus • amylopectin biosynthetic process • response to ethanol • cellular response to hypoxia • glucose transport • carbohydrate transport • transmembrane transport • glucose import in response to insulin stimulus • cellular response to tumor necrosis factor • glucose import • transport • carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6517	20528
Ensembl	ENSG00000181856	ENSMUSG00000018566
UniProt	P14672	P14142
RefSeq (mRNA)	NM_001042	NM_009204
RefSeq (protein)	NP_001033	NP_033230
Location (UCSC)	Chr 17: 7.28 – 7.29 Mb	Chr 17: 69.94 – 69.95 Mb
PubMed search

6517

20528

ENSG00000181856

ENSMUSG00000018566

P14672

P14142

NM_001042

NM_009204

NP_001033

NP_033230

Glucose transporter type 4 (GLUT-4), also known as solute carrier family 2, facilitated glucose transporter member 4, is a protein encoded, in humans, by the SLC2A4 gene. GLUT4 is the insulin-regulated glucose transporter found primarily in adipose tissues and striated muscle (skeletal and cardiac). The first evidence for this distinct glucose transport protein was provided by David James in 1988. The gene that encodes GLUT4 was cloned and mapped in 1989.

At the cell surface, GLUT4 permits the facilitated diffusion of circulating glucose down its concentration gradient into muscle and fat cells. Once within cells, glucose is rapidly phosphorylated by glucokinase in the liver and hexokinase in other tissues to form glucose-6-phosphate, which then enters glycolysis or is polymerized into glycogen. Glucose-6-phosphate cannot diffuse back out of cells, which also serves to maintain the concentration gradient for glucose to passively enter cells.

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Wikipedia