GDF10

Identifiers

GDF10, BMP-3b, BMP3B, growth differentiation factor 10

External IDs

OMIM: 601361 MGI: 95684 HomoloGene: 3640 GeneCards: GDF10

Gene ontology
Molecular function	• transforming growth factor beta receptor binding • cytokine activity • growth factor activity
Cellular component	• extracellular region • extracellular space
Biological process	• regulation of apoptotic process • skeletal system development • positive regulation of pathway-restricted SMAD protein phosphorylation • regulation of MAPK cascade • transforming growth factor beta receptor signaling pathway • SMAD protein signal transduction • fat cell differentiation • cell development • BMP signaling pathway • osteoblast differentiation • negative regulation of osteoblast differentiation • ossification
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2662


14560

Ensembl


ENSG00000266524


ENSMUSG00000021943

UniProt


P55107


P97737

RefSeq (mRNA)


NM_004962


NM_145741

RefSeq (protein)


NP_004953


NP_665684.2 NP_665684

Location (UCSC)

Chr 10: 47.3 – 47.31 Mb

Chr 14: 33.92 – 33.94 Mb

PubMed search

NP_665684.2
NP_665684

Growth differentiation factor 10 (GDF10) also known as bone morphogenetic protein 3B (BMP-3B) is a protein that in humans is encoded by the GDF10 gene.

GDF10 belongs to the transforming growth factor beta superfamily that is closely related to bone morphogenetic protein-3 (BMP3). It plays a role in head formation and may have multiple roles in skeletal morphogenesis. GDF10 is also known as BMP-3b, with GDF10 and BMP3 regarded as a separate subgroup within the TGF-beta superfamily.

In mice, GDF10 mRNA is abundant in the brain, inner ear, uterus, prostate, neural tissues, blood vessels and adipose tissue with low expression in spleen and liver. It is also present in bone of both adults and neonatal mice. Human GDF10 mRNA is found in the cochlea and lung of foetuses, and in testis, retina, pineal gland, and other neural tissues of adults.

...
Wikipedia