Bone morphogenetic protein 3

BMP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QCQ
Identifiers
Aliases	BMP3, BMP-3A, bone morphogenetic protein 3
External IDs	OMIM: 112263 MGI: 88179 HomoloGene: 927 GeneCards: BMP3
Gene ontology Molecular function • cytokine activity • BMP receptor binding • transforming growth factor beta receptor binding • growth factor activity • receptor binding Cellular component • extracellular region • extracellular exosome • extracellular space Biological process • regulation of apoptotic process • skeletal system development • cell differentiation • regulation of MAPK cascade • SMAD protein signal transduction • cell development • ossification • cell-cell signaling • positive regulation of pathway-restricted SMAD protein phosphorylation • BMP signaling pathway • multicellular organism development • cartilage development • osteoblast differentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	651	110075
Ensembl	ENSG00000152785	ENSMUSG00000029335
UniProt	P12645	Q8BHE5
RefSeq (mRNA)	NM_001201	NM_173404 NM_001310677
RefSeq (protein)	NP_001192	NP_775580.1 NP_001297606 NP_775580
Location (UCSC)	Chr 4: 81.03 – 81.06 Mb	Chr 5: 98.85 – 98.88 Mb
PubMed search

2QCQ

651

110075

ENSG00000152785

ENSMUSG00000029335

P12645

Q8BHE5

NM_001201

NM_173404
NM_001310677

NP_001192

NP_775580.1
NP_001297606
NP_775580

Bone morphogenetic protein 3, also known as osteogenin, is a protein in humans that is encoded by the BMP3 gene.

The protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, like other bone morphogenetic proteins (BMP's) is known for its ability to induce bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors.

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Wikipedia