GABRA3

GABRA3
Identifiers
Aliases	GABRA3
External IDs	MGI: 95615 HomoloGene: 20218 GeneCards: GABRA3
Targeted by Drug
gaboxadol, isonipecotic acid, isoguvacine, muscimol, ZK93423, flumazenil, ZK93426, bretazenil, L-822179, methyl 6,7-dimethoxy-4-ethyl-β-carboline-3-carboxylate, ro-15-4513, RO4938581, L-838417, ocinaplon, alprazolam, clonazepam, diazepam, flunitrazepam, triazolam, zolpidem, bicuculline, picrotoxin, CGS8216
Gene ontology Molecular function • GABA-A receptor activity • ion channel activity • protein binding • benzodiazepine receptor activity • chloride channel activity • extracellular ligand-gated ion channel activity Cellular component • integral component of membrane • GABA-A receptor complex • postsynaptic membrane • membrane • plasma membrane • synapse • integral component of plasma membrane • chloride channel complex • cell junction Biological process • gamma-aminobutyric acid signaling pathway • chloride transmembrane transport • ion transport • ion transmembrane transport • transport • chloride transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2556	14396
Ensembl	ENSG00000011677	ENSMUSG00000031343
UniProt	P34903	P26049
RefSeq (mRNA)	NM_000808	NM_008067
RefSeq (protein)	NP_000799	NP_032093.3 NP_032093
Location (UCSC)	Chr X: 152.17 – 152.45 Mb	Chr X: 72.43 – 72.66 Mb
PubMed search

Editing element of GABA-3 exon 9
Conserved secondary structure and sequence conservation of GABA3
Identifiers
Symbol	GABA3
Rfam	RF01803
Other data
RNA type	Cis-reg;
Domain(s)	Eukaryota;
SO	0005836

2556

14396

ENSG00000011677

ENSMUSG00000031343

P34903

P26049

NM_000808

NM_008067

NP_000799

NP_032093.3
NP_032093

Gamma-aminobutyric acid receptor subunit alpha-3 is a protein that in humans is encoded by the GABRA3 gene.

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA_A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA_A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. GABA receptors are composed of 5 subunits with an extracellular ligand binding domains and ion channel domains that are integral to the membrane.Ligand binding to these receptors activates the channel.

Recent research has produced several ligands that are moderately selective for GABA_A receptors containing the α₃ subunit. Subtype-selective agonists for α₃ produce anxiolytic and mild sedative effects, but without causing amnesia or ataxia, which could make them superior to currently marketed drugs.

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Wikipedia