ZK-93423

ZK-93423
Clinical data

ATC code	none
Legal status
Legal status	In general: legal
Identifiers
IUPAC name ethyl 4-(methoxymethyl)-6-(phenylmethoxy) -9H-pyrido[5,4-b]indole-3-carboxylate
CAS Number	83910-44-5^Y
PubChem CID	121926
IUPHAR/BPS	4346
ChemSpider	108771^N
Chemical and physical data
Formula	C₂₃H₂₂N₂O₄
Molar mass	390.431 g/mol
3D model (JSmol)	Interactive image
SMILES c3ccccc3COc(cc4)cc2c4nc(cnc1C(=O)OCC)c2c1COC
InChI InChI=1S/C23H22N2O4/c1-3-28-23(26)22-18(14-27-2)21-17-11-16(29-13-15-7-5-4-6-8-15)9-10-19(17)25-20(21)12-24-22/h4-12,25H,3,13-14H2,1-2H3^N Key:ALBKMJDFBZVHAK-UHFFFAOYSA-N^N
^NY (what is this?)

ZK-93423 is an anxiolytic drug from the β-Carboline family, closely related to abecarnil. It is a nonbenzodiazepine GABA_A agonist which is not subtype selective and stimulates α₁, α₂, α₃, and α₅-subunit containing GABA_A receptors equally. It has anticonvulsant, muscle relaxant and appetite stimulating properties comparable to benzodiazepine drugs. ZK-93423 has also been used as a base to develop new and improved beta-carboline derivatives and help map the binding site of the GABA_A receptor.

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