Estrogen-related receptor beta

ESRRB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LO1
Identifiers
Aliases	ESRRB, DFNB35, ERR2, ERRb, ESRL2, NR3B2, estrogen related receptor beta
External IDs	MGI: 1346832 HomoloGene: 69108 GeneCards: ESRRB
Targeted by Drug
biochanin A, daidzein, genistein, diethylstilbestrol
Gene ontology Molecular function • steroid binding • transcription factor activity, sequence-specific DNA binding • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • zinc ion binding • RNA polymerase II distal enhancer sequence-specific DNA binding • DNA binding • sequence-specific DNA binding • transcription factor binding • metal ion binding • steroid hormone receptor activity • transcription coactivator activity Cellular component • nucleus • nucleoplasm Biological process • regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • embryonic placenta development • transcription, DNA-templated • steroid hormone mediated signaling pathway • transcription initiation from RNA polymerase II promoter • intracellular receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2103	26380
Ensembl	ENSG00000119715	ENSMUSG00000021255
UniProt	O95718	Q61539
RefSeq (mRNA)	NM_004452	NM_001159500 NM_011934
RefSeq (protein)	NP_004443	NP_001152972.1 NP_036064.3 NP_001152972 NP_036064
Location (UCSC)	Chr 14: 76.31 – 76.5 Mb	Chr 12: 86.36 – 86.52 Mb
PubMed search

1LO1

2103

26380

ENSG00000119715

ENSMUSG00000021255

O95718

Q61539

NM_004452

NM_001159500
NM_011934

NP_004443

NP_001152972.1
NP_036064.3
NP_001152972
NP_036064

Estrogen-related receptor beta (ERR-β), also known as NR3B2 (nuclear receptor subfamily 3, group B, member 2), is a nuclear receptor that in humans is encoded by the ESRRB (EStrogen Related Receptor Beta) gene .

This gene encodes a protein with sequence similarity to the estrogen receptor, a member of nuclear hormone receptor family of steroid hormone receptors. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development.

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