Scenic Airlines was started by John & Elizabeth Seibold and their single engine Cessna airplane in North Las Vegas in 1967. Between 1967 and 1993 Scenic Airlines grew to be one of the world's largest fixed-wing air tour operations. In 2000, John Seibold was recognized by the Las Vegas Review Journal as being one of the most influential businessmen in Las Vegas in the previous 100 years. In 1977, Scenic Airlines purchased the design and manufacturing rights to turboprop-powered conversions of the Cessna 402 and Cessna 414 from American Jet Industries. In 1983, the airline co-developed modifications to the de Havilland Canada DHC-6 Twin Otter to make it more suitable for use as an air tour airplane. The airline eventually moved to Las Vegas's McCarran International Airport (LAS).

In 1993 the Seibolds sold the airline to SkyWest Airlines and it continued to see growth until it merged with Eagle Canyon Airlines in 1998. In 1999, Scenic was operating scheduled passenger service between Las Vegas (LAS) and Grand Canyon National Park Airport (GCN) with Fokker F27 turboprops. In the spring of 2006, citing rising fuel costs, the airline announced it would be ceasing scheduled passenger operations in order to focus on its sightseeing flights, thus abandoning its scheduled services using its fleet of three Beechcraft 1900 turboprop aircraft. Almost all of the scheduled service flights were Essential Air Service (EAS) routes and were then picked up by Air Midwest operating as US Airways Express.

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