US Airways Express was the brand name for the regional affiliate of US Airways, under which a number of individually owned commuter air carriers and regional airlines operate short and medium haul routes. This code sharing service was previously operated as USAir Express. Mainline carriers often outsource to regional airlines to operate services in order to increase frequency, serve routes that would not sustain larger aircraft, or for other competitive reasons. US Airways Express operations were conducted from smaller markets in the United States, Canada, and the Bahamas primarily centered on US Airways' major hubs and focus cities. Upon the completion of US Airways' merger process with American Airlines, US Airways Express was rebranded as American Eagle on October 17, 2015.

US Airways Express traced its beginnings to 1967, when Henson Airlines began operating as Allegheny Commuter for Allegheny Airlines, predecessor to US Airways. The initial route was Baltimore-Hagerstown. This is generally credited as the industry's first code-share agreement and the first major airline to use another airline as its commuter partner. Henson Airlines was the major predecessor to today's US Airways Express carrier Piedmont Airlines.

Pacific Southwest Airlines and Piedmont Airlines were both major carriers that merged with USAir, which later became US Airways, and the corporate names were retained to protect their trademarks. However, the routes, aircraft, and other characteristics of the rebranded regional carriers bear no relation to their namesakes.

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