ERα

ESR1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes

1A52, 1ERE, 1ERR, 1G50, 1GWQ, 1GWR, 1HCP, 1HCQ, 1L2I, 1PCG, 1QKT, 1QKU, 1R5K, 1SJ0, 1UOM, 1X7E, 1X7R, 1XP1, 1XP6, 1XP9, 1XPC, 1XQC, 1YIM, 1YIN, 1ZKY, 2AYR, 2B1V, 2B1Z, 2B23, 2BJ4, 2FAI, 2G44, 2G5O, 2I0J, 2IOG, 2IOK, 2JF9, 2JFA, 2LLO, 2LLQ, 2OCF, 2OUZ, 2P15, 2POG, 2Q6J, 2Q70, 2QA6, 2QA8, 2QAB, 2QE4, 2QGT, 2QGW, 2QH6, 2QR9, 2QSE, 2QXM, 2QXS, 2QZO, 2R6W, 2R6Y, 2YAT, 2YJA, 3CBM, 3CBO, 3CBP, 3DT3, 3ERD, 3ERT, 3HLV, 3HM1, 3L03, 3OS8, 3OS9, 3OSA, 3Q95, 3Q97, 3UU7, 3UUA, 3UUC, 3UUD, 4AA6, 4DMA, 4IU7, 4IUI, 4IV2, 4IV4, 4IVW, 4IVY, 4IW6, 4IW8, 4IWC, 4IWF, 4JC3, 4JDD, 4MG5, 4MG6, 4MG7, 4MG8, 4MG9, 4MGA, 4MGB, 4MGC, 4MGD, 4O6F, 4PP6, 4PPP, 4PPS, 4PXM, 4Q13, 4Q50, 4TUZ, 4TV1, 5AK2, 5AAV, 5ACC, 5AAU, 4XI3, 4ZN9, 5FQS, 5FQR, 5FQP, 5FQT, 5FQV, 4ZN7, 5E0W, 5DUG, 4ZUC, 5DXK, 5E19, 5DXQ, 5EI1, 5DXR, 5DVS, 5DZ1, 5E0X, 5DKB, 5DWI, 5E14, 5DXB, 5BPR, 5EIT, 5E15, 4ZNS, 5EGV, 5DL4, 5DWE, 4ZNT, 5EHJ, 5DYD, 5DWG, 4ZNV, 5DWJ, 5DID, 4ZUB, 5BNU, 5DMC, 5DK9, 5DIG, 5DUH, 5DKS, 5DMF, 5DU5, 5DY8, 4ZWH, 5DVV, 5DLR, 4ZWK, 5DRM, 5DP0, 5DKE, 5DZI, 5DZ3, 4ZNU, 5DIE, 5DZ0, 5E1C, 5HYR, 5BQ4, 4ZNW, 5DUE, 5DTV, 5DRJ, 5DKG, 4ZNH, 5BP6, 5DXG, 5DI7, 5DX3, 5DYB, 5DXP, 5DZH, 5DXM

Identifiers

Aliases

ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1, estrogen receptor 1

External IDs

OMIM: 133430 MGI: 1352467 HomoloGene: 47906 GeneCards: ESR1

Genetically Related Diseases

obesity, breast cancer, Alcohol dependence

Targeted by Drug

17β-estradiol, diethylstilbestrol, estriol, estrone, ethinylestradiol, raloxifene, tamoxifen, lasofoxifene, bazedoxifene,

Gene ontology
Molecular function	• transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • nitric-oxide synthase regulator activity • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • estrogen response element binding • transcription factor binding • estrogen receptor activity • metal ion binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • steroid hormone receptor activity • RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding • steroid binding • beta-catenin binding • zinc ion binding • chromatin binding • protein binding • DNA binding • sequence-specific DNA binding • ATPase binding • identical protein binding • lipid binding • core promoter sequence-specific DNA binding • enzyme binding • protein kinase binding
Cellular component	• cytoplasm • membrane • nucleus • transcriptionally active chromatin • nuclear chromatin • integral component of membrane • Golgi apparatus • plasma membrane • nucleoplasm
Biological process	• epithelial cell development • positive regulation of phospholipase C activity • mammary gland alveolus development • transcription from RNA polymerase II promoter • phospholipase C-activating G-protein coupled receptor signaling pathway • epithelial cell proliferation involved in mammary gland duct elongation • prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis • protein localization to chromatin • intracellular estrogen receptor signaling pathway • steroid hormone mediated signaling pathway • regulation of apoptotic process • chromatin remodeling • regulation of transcription, DNA-templated • androgen metabolic process • positive regulation of fibroblast proliferation • mammary gland branching involved in pregnancy • negative regulation of gene expression • transcription, DNA-templated • negative regulation of sequence-specific DNA binding transcription factor activity • cellular response to estrogen stimulus • positive regulation of transcription, DNA-templated • positive regulation of nitric-oxide synthase activity • transcription initiation from RNA polymerase II promoter • regulation of branching involved in prostate gland morphogenesis • male gonad development • positive regulation of sequence-specific DNA binding transcription factor activity • negative regulation of transcription from RNA polymerase II promoter • negative regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of production of miRNAs involved in gene silencing by miRNA • response to estrogen • uterus development • prostate epithelial cord elongation • antral ovarian follicle growth • vagina development • positive regulation of cytosolic calcium ion concentration • positive regulation of nitric oxide biosynthetic process • signal transduction • positive regulation of transcription from RNA polymerase II promoter • intracellular steroid hormone receptor signaling pathway • regulation of inflammatory response • response to estradiol • regulation of toll-like receptor signaling pathway • regulation of transcription from RNA polymerase II promoter • protein deubiquitination • cellular response to estradiol stimulus
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2099


13982

Ensembl


ENSG00000091831


ENSMUSG00000019768

UniProt


P03372


P19785

RefSeq (mRNA)

NM_000125 NM_001122740 NM_001122741 NM_001122742 NM_001291230
NM_001291241 NM_001328100


NM_007956 NM_001302531 NM_001302532 NM_001302533

RefSeq (protein)

NP_000116 NP_001116212 NP_001116213 NP_001116214 NP_001278159
NP_001278170 NP_001315029

NP_001289460.1 NP_001289461.1 NP_031982.1 NP_001289460 NP_001289461
NP_001289462 NP_031982

Location (UCSC)

Chr 6: 151.66 – 152.13 Mb

Chr 10: 4.61 – 5.01 Mb

PubMed search

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