EDA (gene)

EDA
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1RJ7, 1RJ8
Identifiers
Aliases	EDA, ECTD1, ED1, ED1-A1, ED1-A2, EDA-A1, EDA-A2, EDA1, EDA2, HED, HED1, ODT1, STHAGX1, XHED, XLHED, TNLG7C, ectodysplasin A
External IDs	GeneCards: EDA
Gene location (Human) Chr. X chromosome (human) Band Xq13.1 Start 69,616,067 bp End 70,039,469 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding • tumor necrosis factor receptor binding • receptor binding • death receptor agonist activity • death receptor binding Cellular component • integral component of membrane • collagen trimer • endoplasmic reticulum membrane • membrane • plasma membrane • apical part of cell • integral component of plasma membrane • extracellular region • cytoskeleton Biological process • trachea gland development • hair follicle placode formation • hair follicle development • cell differentiation • gene expression • positive regulation of canonical Wnt signaling pathway • salivary gland cavitation • tumor necrosis factor-mediated signaling pathway • multicellular organism development • positive regulation of gene expression • positive regulation of NF-kappaB transcription factor activity • immune response • positive regulation of I-kappaB kinase/NF-kappaB signaling • pigmentation • positive regulation of NF-kappaB import into nucleus • cell-matrix adhesion • skin development • cytokine-mediated signaling pathway • regulation of NIK/NF-kappaB signaling • odontogenesis of dentin-containing tooth Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1896	n/a
Ensembl	ENSG00000158813	n/a
UniProt	Q92838	n/a
RefSeq (mRNA)	NM_001005609 NM_001005610 NM_001005611 NM_001005612 NM_001005613 NM_001005614 NM_001399	n/a
RefSeq (protein)	NP_001005609 NP_001005610 NP_001005612 NP_001005613 NP_001390	n/a
Location (UCSC)	Chr X: 69.62 – 70.04 Mb	n/a
PubMed search		n/a

1RJ7, 1RJ8

1896

n/a

ENSG00000158813

n/a

Q92838

n/a

NM_001005614
NM_001399

n/a

NP_001005609
NP_001005610
NP_001005612
NP_001005613
NP_001390

n/a

Ectodysplasin A (EDA) is a protein that in humans is encoded by the EDA gene.

Ectodysplasin A is a transmembrane protein of the TNF family which plays an important role in the development of ectodermal tissues such as skin in humans. It is recognized by the ectodysplasin A receptor.

The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Along with c-Met, it has been shown to be involved in the differentiation of anatomical placodes, precursors of scales, feathers and hair follicles in vertebrates. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.

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Wikipedia