Ectodysplasin A receptor

EDAR
Identifiers
Aliases	EDAR, DL, ECTD10A, ECTD10B, ED1R, ED3, ED5, EDA-A1R, EDA1R, EDA3, HRM1, ectodysplasin A receptor
External IDs	MGI: 1343498 HomoloGene: 7699 GeneCards: EDAR
Gene location (Human) Chr. Chromosome 2 (human) Band 2q13 Start 108,894,471 bp End 108,989,372 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10 B4|10 29.37 cM Start 58,600,789 bp End 58,675,654 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding • transmembrane signaling receptor activity • receptor activity Cellular component • integral component of membrane • apical part of cell • membrane • plasma membrane Biological process • hair follicle development • odontogenesis of dentin-containing tooth • pigmentation • multicellular organism development • salivary gland cavitation • cell differentiation • positive regulation of gene expression • positive regulation of NF-kappaB import into nucleus • tumor necrosis factor-mediated signaling pathway • epidermis development • apoptotic process • positive regulation of JNK cascade • positive regulation of I-kappaB kinase/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10913	13608
Ensembl	ENSG00000135960	ENSMUSG00000003227
UniProt	Q9UNE0	Q9R187
RefSeq (mRNA)	NM_022336	NM_010100
RefSeq (protein)	NP_071731	NP_034230
Location (UCSC)	Chr 2: 108.89 – 108.99 Mb	Chr 2: 58.6 – 58.68 Mb
PubMed search

10913

13608

ENSG00000135960

ENSMUSG00000003227

Q9UNE0

Q9R187

NM_022336

NM_010100

NP_071731

NP_034230

Ectodysplasin A receptor (EDAR) is a protein that in humans is encoded by the EDAR gene. EDAR is a cell surface receptor for ectodysplasin A which plays an important role in the development of ectodermal tissues such as the skin. It is structurally related to members of the TNF receptor superfamily.

EDAR and other genes provide instructions for making proteins that work together during embryonic development. These proteins form part of a signaling pathway that is critical for the interaction between two cell layers, the ectoderm and the mesoderm. In the early embryo, these cell layers form the basis for many of the body's organs and tissues. Ectoderm-mesoderm interactions are essential for the proper formation of several structures that arise from the ectoderm, including the skin, hair, nails, teeth, and sweat glands.

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