C-Met

MET
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FYR, 1R0P, 1R1W, 1SHY, 1SSL, 2G15, 2RFN, 2RFS, 2UZX, 2UZY, 2WD1, 2WGJ, 2WKM, 3A4P, 3BUX, 3C1X, 3CCN, 3CD8, 3CE3, 3CTH, 3CTJ, 3DKC, 3DKF, 3DKG, 3EFJ, 3EFK, 3F66, 3F82, 3I5N, 3L8V, 3LQ8, 3Q6U, 3Q6W, 3QTI, 3R7O, 3RHK, 3U6H, 3U6I, 3VW8, 3ZBX, 3ZC5, 3ZCL, 3ZXZ, 3ZZE, 4AOI, 4AP7, 4DEG, 4DEH, 4DEI, 4EEV, 4GG7, 4IWD, 4K3J, 4KNB, 4MXC, 4O3T, 4O3U, 4R1V, 4R1Y, 4XMO, 4XYF, 5EYC, 5EYD
Identifiers
Aliases	MET, MET proto-oncogene, receptor tyrosine kinase, AUTS9, HGFR, RCCP2, c-Met, DFNB97, OSFD
External IDs	MGI: 96969 HomoloGene: 206 GeneCards: MET
Genetically Related Diseases
multiple sclerosis
Targeted by Drug
cabozantinib, crizotinib, tivantinib
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • hepatocyte growth factor-activated receptor activity • kinase activity • protein binding • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • protein phosphatase binding • ATP binding • Ras guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • extracellular region • cell surface • basal plasma membrane • intracellular Biological process • negative regulation of hydrogen peroxide-mediated programmed cell death • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of endothelial cell chemotaxis • endothelial cell morphogenesis • protein phosphorylation • cell surface receptor signaling pathway • positive chemotaxis • cell proliferation • negative regulation of autophagy • branching morphogenesis of an epithelial tube • semaphorin-plexin signaling pathway • signal transduction • positive regulation of transcription from RNA polymerase II promoter • peptidyl-tyrosine phosphorylation • hepatocyte growth factor receptor signaling pathway • MAPK cascade • regulation of phosphatidylinositol 3-kinase signaling • entry of bacterium into host cell • positive regulation of GTPase activity • phosphatidylinositol phosphorylation • phosphatidylinositol-mediated signaling Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4233	17295
Ensembl	ENSG00000105976	ENSMUSG00000009376
UniProt	P08581	P16056
RefSeq (mRNA)	NM_000245 NM_001127500 NM_001324401 NM_001324402	NM_008591
RefSeq (protein)	NP_000236 NP_001120972 NP_001311330 NP_001311331	n/a
Location (UCSC)	Chr 7: 116.67 – 116.8 Mb	Chr 6: 17.46 – 17.57 Mb
PubMed search

1FYR, 1R0P, 1R1W, 1SHY, 1SSL, 2G15, 2RFN, 2RFS, 2UZX, 2UZY, 2WD1, 2WGJ, 2WKM, 3A4P, 3BUX, 3C1X, 3CCN, 3CD8, 3CE3, 3CTH, 3CTJ, 3DKC, 3DKF, 3DKG, 3EFJ, 3EFK, 3F66, 3F82, 3I5N, 3L8V, 3LQ8, 3Q6U, 3Q6W, 3QTI, 3R7O, 3RHK, 3U6H, 3U6I, 3VW8, 3ZBX, 3ZC5, 3ZCL, 3ZXZ, 3ZZE, 4AOI, 4AP7, 4DEG, 4DEH, 4DEI, 4EEV, 4GG7, 4IWD, 4K3J, 4KNB, 4MXC, 4O3T, 4O3U, 4R1V, 4R1Y, 4XMO, 4XYF, 5EYC, 5EYD

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