Furin

FURIN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4OMC, 4OMD, 4RYD, 4Z2A
Identifiers
Aliases	FURIN, FUR, PACE, PCSK3, SPC1, furin, paired basic amino acid cleaving enzyme
External IDs	OMIM: 136950 MGI: 97513 HomoloGene: 1930 GeneCards: FURIN
Gene ontology Molecular function • nerve growth factor binding • peptide binding • metal ion binding • protease binding • peptidase activity • protein binding • serine-type endopeptidase inhibitor activity • serine-type peptidase activity • hydrolase activity • serine-type endopeptidase activity • endopeptidase activity Cellular component • integral component of membrane • Golgi apparatus • membrane • Golgi membrane • plasma membrane • cell surface • trans-Golgi network • endoplasmic reticulum • Golgi lumen • membrane raft • trans-Golgi network transport vesicle • extracellular exosome • extracellular region • extracellular space Biological process • cellular protein metabolic process • negative regulation of low-density lipoprotein particle receptor catabolic process • negative regulation of transforming growth factor beta1 production • viral life cycle • secretion by cell • peptide biosynthetic process • protein processing • positive regulation of membrane protein ectodomain proteolysis • extracellular matrix disassembly • extracellular matrix organization • viral protein processing • proteolysis • regulation of low-density lipoprotein particle receptor biosynthetic process • signal peptide processing • peptide hormone processing • regulation of signal transduction • regulation of protein catabolic process • collagen catabolic process • negative regulation of nerve growth factor production • nerve growth factor processing • nerve growth factor production • cell proliferation • transforming growth factor beta receptor signaling pathway • regulation of endopeptidase activity • negative regulation of endopeptidase activity • lipoprotein metabolic process • cornification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5045	18550
Ensembl	ENSG00000140564	ENSMUSG00000030530
UniProt	P09958	P23188
RefSeq (mRNA)	NM_002569 NM_001289823 NM_001289824	NM_001081454 NM_011046
RefSeq (protein)	NP_001276752 NP_001276753 NP_002560 NP_001276752.1 NP_001276753.1 NP_002560.1	NP_001074923.1 NP_035176.1 NP_001074923 NP_035176
Location (UCSC)	Chr 15: 90.87 – 90.88 Mb	Chr 7: 80.39 – 80.41 Mb
PubMed search

4OMC, 4OMD, 4RYD, 4Z2A

5045

18550

ENSG00000140564

ENSMUSG00000030530

P09958

P23188

NM_002569
NM_001289823
NM_001289824

NM_001081454
NM_011046

NP_002560.1

NP_001074923.1
NP_035176.1
NP_001074923
NP_035176

Furin is a protein that in humans is encoded by the FURIN gene. Some proteins are inactive when they are first synthesized, and must have sections removed in order to become active. Furin cleaves these sections and activates the proteins. It was named furin because it was in the upstream region of an oncogene known as FES. The gene was known as FUR (FES Upstream Region) and therefore the protein was named furin. Furin is also known as PACE (Paired basic Amino acid Cleaving Enzyme).

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Wikipedia