Delta hemoglobin

HBD
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1SHR, 1SI4
Identifiers
Aliases	HBD, hemoglobin subunit delta
External IDs	HomoloGene: 128037 GeneCards: HBD
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.4 Start 5,232,678 bp End 5,235,370 bp
Gene ontology Molecular function • iron ion binding • oxygen binding • protein binding • heme binding • metal ion binding • oxygen transporter activity Cellular component • hemoglobin complex • cytosol • blood microparticle Biological process • oxygen transport • blood coagulation • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3045	n/a
Ensembl	ENSG00000223609	n/a
UniProt	P02042	n/a
RefSeq (mRNA)	NM_000519	n/a
RefSeq (protein)	NP_000510	n/a
Location (UCSC)	Chr 11: 5.23 – 5.24 Mb	n/a
PubMed search		n/a

1SHR, 1SI4

3045

n/a

ENSG00000223609

n/a

P02042

n/a

NM_000519

n/a

NP_000510

n/a

Hemoglobin subunit delta is a protein that in humans is encoded by the HBD gene.

The delta (HBD) and beta (HBB) genes are normally expressed in the adult: two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin. Two alpha chains plus two delta chains constitute HbA2, which with HbF comprises the remaining 3% of adult hemoglobin. Five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.

Mutations in the delta-globin gene are associated with Delta-thalassemia.

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