DUSP7

DUSP7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4Y2E
Identifiers
Aliases	DUSP7, MKPX, PYST2, dual specificity phosphatase 7
External IDs	MGI: 2387100 HomoloGene: 1468 GeneCards: DUSP7
Gene ontology Molecular function • phosphoprotein phosphatase activity • phosphatase activity • protein binding • MAP kinase tyrosine/serine/threonine phosphatase activity • hydrolase activity • protein tyrosine phosphatase activity • protein tyrosine/serine/threonine phosphatase activity Cellular component • cytoplasm • cytosol • nucleoplasm Biological process • protein dephosphorylation • MAPK cascade • activation of MAPK activity • negative regulation of MAP kinase activity • peptidyl-tyrosine dephosphorylation • dephosphorylation • inactivation of MAPK activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1849	235584
Ensembl	ENSG00000164086	ENSMUSG00000053716
UniProt	Q16829	Q91Z46
RefSeq (mRNA)	NM_001947	NM_153459
RefSeq (protein)	NP_001938	NP_703189.3 NP_703189
Location (UCSC)	Chr 3: 52.05 – 52.06 Mb	Chr 9: 106.37 – 106.38 Mb
PubMed search

4Y2E

1849

235584

ENSG00000164086

ENSMUSG00000053716

Q16829

Q91Z46

NM_001947

NM_153459

NP_001938

NP_703189.3
NP_703189

Dual specificity protein phosphatase 7 is an enzyme that in humans is encoded by the DUSP7 gene.

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to de-phosphorylate both tyrosine (EC 3.1.3.48) and serine / threonine (EC 3.1.3.16) residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK, JNK, and p38 with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses.

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